beta-Catenin (Phospho-Ser37) Antibody | MyBioSource MBS856938 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

beta-Catenin (Phospho-Ser37) Antibody

catalog :

MBS856938

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS856938

products type :

Antibody

products full name :

beta-Catenin (Phospho-Ser37) Antibody

products short name :

beta-Catenin

products name syn :

b-Catenin (Phospho-Ser37) Antibody

other names :

catenin beta-1; Catenin beta-1; catenin beta-1; catenin (cadherin-associated protein), beta 1, 88kDa; Beta-catenin

other gene names :

CTNNB1; CTNNB1; CTNNB; MRD19; armadillo; CTNNB

uniprot entry name :

CTNB1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

781

specificity :

beta-Catenin (phospho-Ser37) antibody detects endogenous levels of beta-Catenin only when phosphorylated at serine 37.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

50ug/50ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human beta-Catenin around the phosphorylation site of serine 37 (I-H-SP-G-A). Pathway: Wnt/beta-catenin

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Novak A, et al. (1998) Proc Natl Acad Sci U S A; 95(8): 4374-4379. Marin O, et al. (2003) Proc Natl Acad Sci U S A; 100(18): 10193-10200. Okamura H, et al. (2004) Mol Cell Biol; 24(10): 4184-4195. Xing Y, et al. (2003) Genes Dev; 17(22): 2753-2764. Barth AI, et al. (1999) Proc Natl Acad Sci U S A; 96(9): 4947-4952

ncbi gi num :

148233338

ncbi acc num :

NP_001091679.1

ncbi gb acc num :

NM_001098209.1

uniprot acc num :

P35222

ncbi mol weight :

9,501 Da

ncbi pathways :

AMER1 Mutants Destabilize The Destruction Complex Pathway (1016198); APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway (1016193); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1016194); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1016197); AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway (1016195); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Adherens Junctions Interactions Pathway (119533); Adipogenesis Pathway (198832); Androgen Receptor Signaling Pathway (198806)

ncbi summary :

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]

uniprot summary :

CTNNB1: a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Protein type: Cell adhesion; Motility/polarity/chemotaxis; Actin-binding; Oncoprotein; Nuclear receptor co-regulator; Transcription factor. Chromosomal Location of Human Ortholog: 3p21. Cellular Component: centrosome; basolateral plasma membrane; fascia adherens; intercellular junction; beta-catenin destruction complex; cytosol; transcription factor complex; cell-cell adherens junction; membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; synapse; dendritic shaft; lateral plasma membrane; spindle pole; focal adhesion; tight junction; cell cortex; catenin complex; Z disc; nucleoplasm; adherens junction; microvillus membrane; apical part of cell; plasma membrane; cell junction; nucleus. Molecular Function: protein C-terminus binding; transcription coactivator activity; transcription factor binding; protein phosphatase binding; ionotropic glutamate receptor binding; protein binding; signal transducer activity; enzyme binding; androgen receptor binding; cadherin binding; double-stranded DNA binding; protein complex binding; estrogen receptor binding; nitric-oxide synthase binding; SMAD binding; kinase binding; transcription factor activity; alpha-catenin binding; nuclear hormone receptor binding. Biological Process: regulation of myelination; regulation of centriole-centriole cohesion; positive regulation of apoptosis; protein heterooligomerization; positive regulation of transcription, DNA-dependent; regulation of fibroblast proliferation; cell maturation; negative regulation of chondrocyte differentiation; T cell differentiation in the thymus; positive regulation of fibroblast growth factor receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; osteoclast differentiation; cell-cell adhesion; positive regulation of endothelial cell differentiation; regulation of cell fate specification; positive regulation of mesenchymal cell proliferation; embryonic foregut morphogenesis; synapse organization and biogenesis; ectoderm development; male genitalia development; cell adhesion; bone resorption; response to drug; positive regulation of neuroblast proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of smooth muscle cell proliferation; transcription, DNA-dependent; hair cell differentiation; negative regulation of protein sumoylation; genitalia morphogenesis; patterning of blood vessels; muscle cell differentiation; midgut development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; oocyte development; embryonic forelimb morphogenesis; negative regulation of osteoclast differentiation; glial cell fate determination; endodermal cell fate commitment; apoptosis; cell-matrix adhesion; neuron migration; cell fate specification; dorsal/ventral axis specification; positive regulation of histone H3-K4 methylation; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; response to estradiol stimulus; negative regulation of cell proliferation; central nervous system vasculogenesis; positive regulation of MAPKKK cascade; pancreas development; positive regulation of interferon type I production; fallopian tube development; layer formation in the cerebral cortex; proximal/distal pattern formation; cell structure disassembly during apoptosis; negative regulation of mitotic cell cycle, embryonic; Wnt receptor signaling pathway; hair follicle morphogenesis; thymus development; in utero embryonic development; stem cell maintenance; regulation of T cell proliferation; neural plate development; embryonic axis specification; synaptic vesicle transport; gastrulation with mouth forming second; liver development; regulation of angiogenesis; odontogenesis of dentine-containing teeth; negative regulation of oligodendrocyte differentiation; myoblast differentiation; Schwann cell proliferation; positive regulation of osteoblast differentiation; response to cadmium ion; ureteric bud branching; response to cytokine stimulus; androgen receptor signaling pathway; innate immune response; epithelial to mesenchymal transition; positive regulation of muscle cell differentiation; embryonic heart tube development; lens morphogenesis in camera-type eye; anterior/posterior axis specification. Disease: Pilomatrixoma; Mental Retardation, Autosomal Dominant 19; Ovarian Cancer; Colorectal Cancer; Hepatocellular Carcinoma

size1 :

0.1 mg

price1 :

215 USD

size2 :

0.05 mg

price2 :

225

more info or order :

MyBioSource product webpage