FGFR1 (Phospho-Tyr154) Antibody | MyBioSource MBS856782 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

FGFR1 (Phospho-Tyr154) Antibody

catalog :

MBS856782

quantity :

0.05 mg

price :

225 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

catalog number :

MBS856782

products type :

Antibody

products full name :

FGFR1 (Phospho-Tyr154) Antibody

products short name :

FGFR1

other names :

fibroblast growth factor receptor 1 isoform 10; Fibroblast growth factor receptor 1; fibroblast growth factor receptor 1; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD_antigen: CD331

products gene name :

FGFR1

other gene names :

FGFR1; FGFR1; CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; FGFR-1; BFGFR; bFGF-R-1; FLT-2

uniprot entry name :

FGFR1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

820

specificity :

FGFR1 (Phospho-Tyr154) antibody detects endogenous levels of FGFR1 only when phosphorylated at tyrosine 154.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

50ug/50ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:4000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human FGFR1 around the phosphorylation site of RMPVAPYWTSPEK tyrosine 154 (A-P-YP-W-T). Pathway: Tyrosine kinase

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

DiGabriele A.D., et al. (1998) Nature 393:812-817. Cross M.J., et al. Mol. (2002) Biol. Cell 13:2881-2893. Hinsby AM, Olsen JV, Bennett KL, Mann M (2003) Mol Cell Proteomics 2, 29-36. Powers, C.J. et al. (2000) Endocr Relat Cancer 7, 165-97. Reilly, J.F. et al. (2000) J Biol Chem 275, 7771-8. Mohammadi, M. et al. (1996) Mol Cell Biol 16, 977-89.

ncbi gi num :

291327489

ncbi acc num :

NP_001167534.1

ncbi gb acc num :

NM_001174063.1

uniprot acc num :

P11362

ncbi mol weight :

95,344 Da

ncbi pathways :

Adaptive Immune System Pathway 366160!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Axon Guidance Pathway 105688!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550!!Developmental Biology Pathway 477129!!Disease Pathway 530764!!Downstream Signal Transduction Pathway 106385

ncbi summary :

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

size :

0.05 mg

price :

225 USD