CD133 Antibody | MyBioSource MBS856765 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD133 Antibody

catalog :

MBS856765

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS856765

products type :

Antibody

products full name :

CD133 Antibody

products short name :

CD133

other names :

prominin-1 isoform 2; Prominin-1; prominin-1; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen; prominin 1; Antigen AC133; Prominin-like protein 1; CD_antigen: CD133

products gene name :

CD133

other gene names :

PROM1; PROM1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; PROML1

uniprot entry name :

PROM1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

856

purity :

Antigen affinity purification

form :

Each vial at least contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.1% sodium azide.

concentration :

1mg/1ml

storage stability :

Store at 4 degree C or -20 degree C (with 50% glycerol); Minimize freeze-thaw cycles; Non-hazardous.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500-1000. Other applications have not been tested.

other info1 :

Limitation: For research use only and are not intented for diagnostic or therapeutic use.

other info2 :

Immunogen: Recombinant C terminal 300aa of human CD133. Species: Rabbit

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: PROM1, also named as PROML1, CD133 and AC133, belongs to the prominin family. PROM1 interacts with PCDH21 and with actin filaments. CD133 is a cance stem cell marker. Defects in PROM1 are the cause of retinitis pigmentosa type 41 (RP41)which also known as retinal degeneration autosomal recessive prominin-related. Defects in PROM1 are the cause of cone-rod dystrophy type 12 (CORD12). Defects in PROM1 are the cause of Stargardt disease type 4 (STGD4). Defects in PROM1 are the cause of retinal macular dys trophy type 2 (MCDR2). The antibody recognizes transcript variant 1,6,7 of PROM1.

ncbi gi num :

224994189

ncbi acc num :

NP_001139319.1

ncbi gb acc num :

NM_001145847.1

ncbi mol weight :

94,605 Da

ncbi pathways :

Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

uniprot summary :

CD133: Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Interacts with CDHR1 and with actin filaments. Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells. Expressed in adult retina by rod and cone photoreceptor cells. Belongs to the prominin family. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cell surface. Chromosomal Location of Human Ortholog: 4p15.32. Cellular Component: stereocilium; extracellular space; photoreceptor outer segment; cell surface; microvillus membrane; integral to plasma membrane; endoplasmic reticulum; apical plasma membrane; ER-Golgi intermediate compartment; plasma membrane; brush border; vesicle. Molecular Function: actinin binding; protein binding; cadherin binding. Biological Process: photoreceptor cell maintenance; retina morphogenesis in camera-type eye. Disease: Stargardt Disease 4; Macular Dystrophy, Retinal, 2; Retinitis Pigmentosa 41; Cone-rod Dystrophy 12

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage