CDK6 (phospho-Tyr13) Antibody | MyBioSource MBS856753 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CDK6 (phospho-Tyr13) Antibody

catalog :

MBS856753

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS856753

products type :

Antibody

products full name :

CDK6 (phospho-Tyr13) Antibody

products short name :

CDK6

other names :

cyclin-dependent kinase 6; Cyclin-dependent kinase 6; cyclin-dependent kinase 6; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE; cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE

products gene name :

CDK6

other gene names :

CDK6; CDK6; MCPH12; PLSTIRE; CDKN6

uniprot entry name :

CDK6_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

326

specificity :

CDK6 (phospho-Tyr13) Antibody detects endogenous levels of CDK6 only when phosphorylated at tyrosine 13.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

50ug/50ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

IHC: 1:50~100, IF:1:100~1:200

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human CDK6 around the phosphorylation site of tyrosine 13 (Q-Q-YP-E-C). Pathway: Cancer/Apoptosis, CellCycle, Kinase/Phosphatases

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Lukas, J. et al. (1996) Mol. Cell. Biol. 16, 6917-1625. Hirai, H. et al. (1995) Mol. Cell. Biol. 15, 2672-2681. Flores-Rozas, H. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 8655-8659.

ncbi gi num :

223718134

ncbi acc num :

NP_001138778.1

ncbi gb acc num :

NM_001145306.1

uniprot acc num :

Q00534

ncbi mol weight :

36,938 Da

ncbi pathways :

B Cell Receptor Signaling Pathway (198909); C-MYB Transcription Factor Network Pathway (138073); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Chronic Myeloid Leukemia Pathway (83116)

ncbi summary :

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

uniprot summary :

CDK6: a protein kinase of the CDK family. Important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. Phosphorylates and regulates the activity of the Rb tumor suppressor protein. Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas and rodent cancers. Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; Protein kinase, CMGC; Kinase, protein; Cell cycle regulation; CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily. Chromosomal Location of Human Ortholog: 7q21-q22. Cellular Component: nucleoplasm; ruffle; centrosome; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleus. Molecular Function: protein binding; cyclin binding; cyclin-dependent protein kinase activity; ATP binding. Biological Process: Notch signaling pathway; dentate gyrus development; negative regulation of myeloid cell differentiation; response to virus; gliogenesis; T cell differentiation in the thymus; protein amino acid phosphorylation; astrocyte development; negative regulation of cell cycle; regulation of erythrocyte differentiation; negative regulation of cell proliferation; negative regulation of cell differentiation; positive regulation of fibroblast proliferation; regulation of gene expression; cell division; generation of neurons; cell dedifferentiation; negative regulation of osteoblast differentiation; mitotic cell cycle; cell cycle arrest; positive regulation of cell-matrix adhesion; lateral ventricle development; negative regulation of epithelial cell proliferation; G1/S transition of mitotic cell cycle. Disease: Microcephaly 12, Primary, Autosomal Recessive

size1 :

0.1 mg

price1 :

215 USD

size2 :

0.05 mg

price2 :

225

more info or order :

MyBioSource product webpage