cofilin1 (phospho-Tyr139) Antibody | MyBioSource MBS856748 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

cofilin1 (phospho-Tyr139) Antibody

catalog :

MBS856748

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS856748

products type :

Antibody

products full name :

cofilin1 (phospho-Tyr139) Antibody

products short name :

cofilin1

other names :

cofilin-1; Cofilin-1; cofilin-1; p18; 18 kDa phosphoprotein; cofilin, non-muscle isoform; epididymis secretory protein Li 15; cofilin 1 (non-muscle); 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform

other gene names :

CFL1; CFL1; CFL; HEL-S-15; CFL; p18

uniprot entry name :

COF1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

166

specificity :

cofilin1 (phospho-Tyr139) Antibody detects endogenous levels of cofilin1 only when phosphorylated at tyrosine 139.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

50ug/50ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Immunohistochemistry (IHC)

app notes :

IHC: 1:50~100

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human cofilin1 around the phosphorylation site of tyrosine 139 (N-C-YP-E-E). Pathway: Cytoskeletal/Adhesion

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Carlier, M. et al. (1999) J. Biol. Chem. 274, 33827-33830. Arber, S. et al. (1998) Nature 393, 805-809. Yang, N. et al. (1998) Nature 393, 809-812.

ncbi gi num :

5031635

ncbi acc num :

NP_005498.1

ncbi gb acc num :

NM_005507.2

uniprot acc num :

P23528

ncbi mol weight :

18,502 Da

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); BDNF Signaling Pathway (712093); CDC42 Signaling Events Pathway (137994); CXCR4-mediated Signaling Events Pathway (137910); Developmental Biology Pathway (477129); EPH-Ephrin Signaling Pathway (1016174); EPHB-mediated Forward Signaling Pathway (1016176); Fc Gamma R-mediated Phagocytosis Pathway (114228)

ncbi summary :

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

uniprot summary :

Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Cytoskeletal. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: extracellular space; cortical actin cytoskeleton; nuclear matrix; focal adhesion; membrane; cytoplasm; intercellular junction; nucleus; vesicle. Molecular Function: protein binding; actin binding. Biological Process: axon guidance; platelet activation; actin filament depolymerization; positive regulation of actin filament depolymerization; response to virus; negative regulation of cell size; cytoskeleton organization and biogenesis; response to amino acid stimulus; protein amino acid phosphorylation; Rho protein signal transduction; neural fold formation; platelet degranulation; cytokinesis after mitosis; protein import into nucleus; establishment of cell polarity; ephrin receptor signaling pathway; innate immune response; regulation of cell morphogenesis; actin cytoskeleton organization and biogenesis; blood coagulation; neural crest cell migration; negative regulation of apoptosis

size1 :

0.1 mg

price1 :

215 USD

size2 :

0.05 mg

price2 :

225

more info or order :

MyBioSource product webpage