product summary
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company name :
MyBioSource
product type :
antibody
product name :
Protocadherin Fat 1 Antibody
catalog :
MBS856736
quantity :
0.1 mL
price :
290 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunocytochemistry
more info or order :
product information
catalog number :
MBS856736
products type :
Antibody
products full name :
Protocadherin Fat 1 Antibody
products short name :
Protocadherin Fat 1
other names :
protocadherin Fat 1; Protocadherin Fat 1; protocadherin Fat 1; cadherin ME5; protein fat homolog; FAT tumor suppressor 1; cadherin family member 7; FAT tumor suppressor homolog 1; cadherin-related family member 8; cadherin-related tumor suppressor homolog; FAT atypical cadherin 1; Cadherin family member 7; Cadherin-related tumor suppressor homolog; Protein fat homologCleaved into the following chain:Protocadherin Fat 1, nuclear form
other gene names :
FAT1; FAT1; FAT; ME5; CDHF7; CDHR8; hFat1; CDHF7; FAT
uniprot entry name :
FAT1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
4588
specificity :
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to the residues of Fat1.
form :
Liquid
tested application :
Western Blot (WB) , Immunocytochemistry (ICC)
app notes :
WB: 1:2,000-5,000, ICC: 1:100
other info2 :
Immunogen: affinity purified. Cellular Localization: Cell membrane
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products description :
Background: Mammalian FAT1 is a large transmembrane protein of the protocadherin superfamily first identified in Drosophila melanogaster. FAT1 is widely expressed in mammalian tissues, and it is particularly enriched in kidney glomerular epithelial cells. Human Protocadherin Fat1 is a single-pass type I membrane protein, contains 4950 amino acids. It may play an important role in regulating growth and cell adhesion.
products references :
1. "Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule."Dunne J., Hanby A.M., Poulsom R., Jones T.A., Sheer D., Chin W.G., Da S.M., Zhao Q., Beverley P.C.L., Owen M.J.Genomics 30:207-223(1995). 2. "Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization" Marcus J Moeller, Abdulsalam Soofi, Gerald S Braun1, Xiaodong Li, Carsten Watzl2, Wilhelm Kriz1 and Lawrence B Holzman. The EMBO Journal 23:3769-3779(2004)
ncbi gi num :
66346693
ncbi acc num :
NP_005236.2
ncbi gb acc num :
NM_005245.3
uniprot acc num :
Q14517
ncbi mol weight :
50kDa
ncbi summary :
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
uniprot summary :
FAT: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 4q35. Cellular Component: focal adhesion; lamellipodium; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; intercellular junction; nucleus; filopodium. Molecular Function: protein binding; calcium ion binding. Biological Process: cell-cell adhesion; cell migration; anatomical structure morphogenesis; cell-cell signaling; establishment and/or maintenance of cell polarity; actin filament organization; homophilic cell adhesion; cell adhesion
size1 :
0.1 mL
price1 :
290 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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