ICAM-1(Ab-512) Antibody | MyBioSource MBS856703 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ICAM-1(Ab-512) Antibody

catalog :

MBS856703

quantity :

0.05 mg

price :

180 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS856703

products type :

Antibody

products full name :

ICAM-1(Ab-512) Antibody

products short name :

ICAM-1

other names :

intercellular adhesion molecule 1; Intercellular adhesion molecule 1; intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule 1; Major group rhinovirus receptor; CD_antigen: CD54

products gene name :

ICAM-1

other gene names :

ICAM1; ICAM1; BB2; CD54; P3.58; ICAM-1

uniprot entry name :

ICAM1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

532

specificity :

ICAM-1 (Ab-512) antibody detects endogenous levels of total ICAM-1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

50ug/50ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB)

app notes :

WB: 1:500~1:1000

other info2 :

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human ICAM-1 around the phosphorylation site of tyrosine 512 (K-K-YP-R-L). Pathway: Cytoskeleta/Adhesion

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Greenwood J, et al. (2003) J Immunol; 171(4):2099-2108. Zhou Z, et al. (2005) Eur J Pharmacol; 513(1-2):1-8. Chen YH, et al. (2001) J Cell Biochem; 82(3):512-521

ncbi gi num :

167466198

ncbi acc num :

NP_000192.2

ncbi gb acc num :

NM_000201.2

uniprot acc num :

P05362

ncbi mol weight :

57,825 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cytokine Signaling In Immune System Pathway (366171); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Extracellular Matrix Organization Pathway (576262); Glucocorticoid Receptor Regulatory Network Pathway (138014)

ncbi summary :

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

uniprot summary :

ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. Protein type: Membrane protein, integral; Cell adhesion; Immunoglobulin superfamily. Chromosomal Location of Human Ortholog: 19p13.3-p13.2. Cellular Component: extracellular space; focal adhesion; cell surface; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane. Molecular Function: viral receptor activity; integrin binding; protein binding; transmembrane receptor activity; receptor activity. Biological Process: entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; regulation of cell adhesion; response to drug; virion attachment, binding of host cell surface receptor; regulation of immune response; negative regulation of calcium ion transport; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; positive regulation of actin filament polymerization; response to copper ion; positive regulation of vasoconstriction; adhesion to host; cell adhesion mediated by integrin; response to ionizing radiation; leukocyte migration. Disease: Malaria, Susceptibility To

size1 :

0.05 mg

price1 :

180 USD

size2 :

0.1 mg

price2 :

215

more info or order :

MyBioSource product webpage