catalog number :
MBS856675
products full name :
Connexin 43 (Ab-367) Antibody
products short name :
Connexin 43
other names :
gap junction alpha-1 protein; Gap junction alpha-1 protein; gap junction alpha-1 protein; connexin 43; connexin-43; gap junction 43 kDa heart protein; gap junction protein, alpha 1, 43kDa; Connexin-43; Cx43; Gap junction 43 kDa heart protein
other gene names :
GJA1; GJA1; HSS; CMDR; CX43; GJAL; ODDD; AVSD3; HLHS1; GJAL; Cx43
uniprot entry name :
CXA1_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Connexin43 (Ab-367) antibody detects endogenous levels of total Connexin43 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
50ug/50ul
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500~1:1000, IHC: 1:50~1:100
other info2 :
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Connexin43 around the phosphorylation site of serine 367 (R-A-SP-S-R). Pathway: Cytoskeletal/Adhesion, Channel
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Joell L. Solan1, et al. (2003) Cell Science 116: 2203-2211. Satoshi Matsushita, et al. (2006) Histochemistry and Cytochemistry 54 (3): 343-353,. Xiaoyong Bao, et al. (2004) Cell Physiol 286: C647-C654. W. E. I. Li, et al.(1998) European Journal of Neuroscience 10: 2444
ncbi acc num :
NP_000156.1
ncbi gb acc num :
NM_000165.4
ncbi mol weight :
43,008 Da
ncbi pathways :
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway 672454!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 117293!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 116129!!Calcium Regulation In The Cardiac Cell Pathway 198906!!Corticotropin-releasing Hormone Pathway 920957!!EGFR1 Signaling Pathway 198782!!Formation Of Annular Gap Junctions Pathway 105934!!Gap Junction Pathway 83072!!Gap Junction Pathway 483!!Gap Junction Assembly Pathway 105928
ncbi summary :
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]