TG2 Antibody-HRP | MyBioSource MBS856645 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TG2 Antibody-HRP

catalog :

MBS856645

quantity :

0.1 mL

price :

355 USD

clonality :

polyclonal

host :

rabbit

conjugate :

HRP

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS856645

products type :

Antibody

products full name :

TG2 Antibody-HRP

products short name :

TG2

other names :

Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine gamma-glutamyltransferase 2; TG(C); TGase C; TGase H; TGase-2; TGase-H; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; epididymis secretory protein Li 45; protein-glutamine-gamma-glutamyltransferase; C polypeptide, protein-glutamine-gamma-glutamyltransferase; transglutaminase 2; Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2

products gene name :

TG2

other gene names :

TGM2; TGM2; TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h; TG(C); TGC; TGase C; TGase H; TGase-2

uniprot entry name :

TGM2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

548

specificity :

Recognizes an epitope on the TrypsinogenII Antigen.

purity :

>95% pure (SDS-PAGE). Protein G chromatography. Product is 0.2um filtered

form :

Purified, Liquid

concentration :

100ug/100ul

storage stability :

Short-term store at 2-8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.

tested application :

ELISA (EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB)

app notes :

IHC: 1:1000~5000. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded

other info2 :

Immunogen: Human TrypsinogenII Antigen

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: PcAb to TG2 antibody. Rabbit Anti Human TrypsinogenII Antibody

ncbi gi num :

13097681

ncbi acc num :

AAH03551.1

ncbi mol weight :

38,671 Da

ncbi pathways :

Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Thromboxane A2 Receptor Signaling Pathway (138060)

ncbi summary :

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described. Protein type: EC 2.3.2.13; Transferase. Chromosomal Location of Human Ortholog: 20q12. Cellular Component: focal adhesion; mitochondrion; plasma membrane; cytosol. Molecular Function: protein domain specific binding; protein binding; GTP binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding. Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cell adhesion; positive regulation of apoptosis; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; positive regulation of smooth muscle cell proliferation; reduction of endoplasmic reticulum calcium ion concentration; blood vessel remodeling; protein homooligomerization; apoptotic cell clearance; positive regulation of inflammatory response; elevation of mitochondrial calcium ion concentration

size1 :

0.1 mL

price1 :

355 USD

more info or order :

MyBioSource product webpage