antibody

apelin Antibody

MBS856614

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

human, mouse

Antibody

apelin Antibody

apelin

Mus musculus apelin (Apln), mRNA; Apelin; apelin; preproapelin; APJ endogenous ligand; apelin; APJ endogenous ligandCleaved into the following 4 chains:Apelin-36; Apelin-31; Apelin-28; Apelin-13

Apln; Apln; Apel; 6030430G11Rik; Apel

APEL_MOUSE

Polyclonal

Rabbit

Human, Mouse

3148

apelin antibody purified by peptide affinity column containing 2% BSA and 0.02% NaN3.

100ug/200ul

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

Peptide ELISA titer: 1:10,000-1:40,000. Immunohistochemistry: 1:50-200. Optimal dilutions/concentrations should be determined by the end user.

Source Note: Rabbit polyclonal apelin (1) antibody was raised against a peptide from near the C terminal residues of human apelin protein. Reactivity Note: Not yet tested in other species.

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

(1) D'Aniello,C., Lonardo,E., Iaconis,S., et al. G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway. Circ. Res. 105 (3), 231-238 (2009)

123702126

NP_038940.1

NM_013912

8,658 Da

Class A/1 (Rhodopsin-like Receptors) Pathway (1000942); G Alpha (i) Signalling Events Pathway (1000973); GPCR Downstream Signaling Pathway (1000971); GPCR Ligand Binding Pathway (1000941); Peptide Ligand-binding Receptors Pathway (1000943); Signal Transduction Pathway (970540); Signaling By GPCR Pathway (971377)

apelin: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. Belongs to the apelin family. Protein type: Secreted, signal peptide; Secreted. Cellular Component: extracellular space; perinuclear region of cytoplasm. Molecular Function: G-protein-coupled receptor binding; hormone activity; apelin receptor binding; receptor binding. Biological Process: drinking behavior; positive regulation of vasodilation; signal transduction; negative regulation of vasoconstriction; positive regulation of corticotropin-releasing hormone secretion; positive regulation of adrenocorticotropic hormone secretion; G-protein coupled receptor protein signaling pathway; regulation of body fluid levels; positive regulation of heat generation; regulation of respiratory gaseous exchange; positive regulation of cell proliferation; feeding behavior; negative regulation of blood pressure; regulation of the force of heart contraction; positive regulation of phosphorylation

0.1 mg

290 USD