Cytochrome P450 21A2 Antibody | MyBioSource MBS856347 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Cytochrome P450 21A2 Antibody

catalog :

MBS856347

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS856347

products type :

Antibody

products full name :

Cytochrome P450 21A2 Antibody

products short name :

Cytochrome P450 21A2

products name syn :

Cytochrome P450 21; EC 1.14.99.10; Cytochrome P450 XXI; Steroid 21-hydroxylase; 21-Ohase; P450-C21; P-450c21; P450-C21B; CYP21; CYP21B; CP21A

other names :

steroid 21-hydroxylase isoform a; Steroid 21-hydroxylase; steroid 21-hydroxylase; 21-OHase; cytochrome P450 XXI; cytochrome P450-C21B; steroid 21-monooxygenase; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2; cytochrome P450, family 21, subfamily A, polypeptide 2; 21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B

other gene names :

CYP21A2; CYP21A2; CAH1; CPS1; CA21H; CYP21; CYP21B; P450c21B; CYP21; CYP21B

uniprot entry name :

CP21A_HUMAN

host :

Rabbit

reactivity :

Human

sequence length :

495

specificity :

Cytochrome P450 21A2 antibody detects endogenous levels of total Cytochrome P450 21A2 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human Cytochrome P450 21A2. Pathway: Translation

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Helmberg A., Mol. Endocrinol. 6:1318-1322(1992). Collier S., Nat. Genet. 3:260-265(1993). White P.C., Hum. Mutat. 3:373-378(1994). ------------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

323510663

ncbi acc num :

NP_000491.4

ncbi gb acc num :

NM_000500.7

uniprot acc num :

P08686

ncbi mol weight :

52,597 Da

ncbi pathways :

Biological Oxidations Pathway (105698); C21-Steroid Hormone Biosynthesis, Progesterone = Corticosterone/aldosterone Pathway (413394); C21-Steroid Hormone Biosynthesis, Progesterone = Corticosterone/aldosterone Pathway (468295); C21-Steroid Hormone Biosynthesis, Progesterone = Cortisol/cortisone Pathway (413395); C21-Steroid Hormone Biosynthesis, Progesterone = Cortisol/cortisone Pathway (468370); Corticotropin-releasing Hormone Pathway (920957); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Endogenous Sterols Pathway (105701); Glucocorticoid Mineralcorticoid Metabolism Pathway (198902); Glucocorticoid Biosynthesis Pathway (106152)

ncbi summary :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

CYP21A2: Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. Defects in CYP21A2 are the cause of adrenal hyperplasia type 3 (AH3). AH3 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: salt wasting (SW, the most severe type), simple virilizing (SV, less severely affected patients), with normal aldosterone biosynthesis, non-classic form or late onset (NC or LOAH), and cryptic (asymptomatic). Belongs to the cytochrome P450 family. Protein type: EC 1.14.99.10; Oxidoreductase; Lipid Metabolism - C21-steroid hormone. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: endoplasmic reticulum membrane. Molecular Function: steroid 21-monooxygenase activity; iron ion binding; heme binding; steroid hydroxylase activity; steroid binding. Biological Process: steroid metabolic process; xenobiotic metabolic process; mineralocorticoid biosynthetic process; glucocorticoid biosynthetic process; sterol metabolic process. Disease: Adrenal Hyperplasia, Congenital, Due To 21-hydroxylase Deficiency

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage