product summary
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company name :
MyBioSource
product type :
antibody
product name :
OSR1 (Phospho-Thr185) Antibody
catalog :
MBS856192
quantity :
0.1 mg
price :
215 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
product information
catalog number :
MBS856192
products type :
Antibody
products full name :
OSR1 (Phospho-Thr185) Antibody
products short name :
OSR1
products name syn :
EC 2.7.11.1; kinase OSR1; Oxidative-stress responsive 1; Oxidative-stress responsive 1 homolog; OXSR1
other names :
serine/threonine-protein kinase OSR1; Serine/threonine-protein kinase OSR1; serine/threonine-protein kinase OSR1; OXSR1; oxidative-stress responsive 1; oxidative stress-responsive 1 protein; oxidative stress responsive 1; Oxidative stress-responsive 1 protein
products gene name :
OSR1
other gene names :
OXSR1; OXSR1; OSR1
uniprot entry name :
OXSR1_HUMAN
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
527
specificity :
OSR1 (Phospho-Thr185) antibody detects endogenous levels of OSR1 only when phosphorylated at threonine 185.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
app notes :
WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:10000
other info1 :
Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%)
other info2 :
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human OSR1 around the phosphorylation site of threonine 185 (R-K-TP-F-V). All Sites: Human: Thr185; Mouse: Thr185. Pathway: Phospho-specific
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Tamari M., J. Hum. Genet. 44:116-120(1999). Kikuno R., DNA Res. 6-197-205(1999). The MGC Project Team; Genome Res. 14:2121-2127(2004).
ncbi gi num :
4826878
ncbi acc num :
NP_005100.1
ncbi gb acc num :
NM_005109.2
uniprot acc num :
O95747
ncbi mol weight :
58,022 Da
ncbi summary :
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
uniprot summary :
OSR1: oxidative-stress responsive 1 protein is a ubiquitously expressed protein kinase of the STE20 family. Regulates Na-K-Cl cotransporter (NKCC) activity. Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Binds to and phosphorylates PAK1. Interacts and is phosphorylated by WNK1. Knockdown of either WNK1 or OXSR1 reduces NKCC activity. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. An important paralog of this gene is STRADB. Protein type: EC 2.7.11.1; Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; FRAY subfamily. Chromosomal Location of Human Ortholog: 3p22.2. Cellular Component: cytoplasm. Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity. Biological Process: peptidyl-threonine phosphorylation; response to oxidative stress; protein amino acid phosphorylation
size1 :
0.1 mg
price1 :
215 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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