catalog number :
MBS856175
products full name :
Amylin Antibody
products short name :
[Amylin]
products name syn :
[Islet amyloid polypeptide [Precursor]; Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide; IAPP]
other names :
[islet amyloid polypeptide preproprotein; Islet amyloid polypeptide; islet amyloid polypeptide; islet amyloid polypeptide; Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide]
other gene names :
[IAPP; IAPP; DAP; IAP; DAP]
specificity :
Amylin antibody detects endogenous levels of total amylin protein.
purity :
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year
tested application :
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
app notes :
WB: 1:500~1:1000. IHC: 1:50~1:100. ELISA: 1:10000
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Western Blot (WB)
other info1 :
Immunogen: The antiserum was produced against synthesized peptide derived from human amylin(HQVEKRKC).
products references :
U Zimmermann, J. Endocrinol., Dec 1997; 155: 423-431. Peter J. Wookey, Hypertension, Sep 1997; 30: 455. M Alevizaki, Eur. J. Endocrinol., Nov 2001; 145: 585-589. Jack H. Jhamandas, J Neurophysiol, Jun 2003; 89: 2923.
ncbi acc num :
NP_000406.1
ncbi gb acc num :
NM_000415.2
ncbi mol weight :
9,806 Da
ncbi pathways :
Amyloids Pathway (366238); Calcitonin-like Ligand Receptors Pathway (106379); Class B/2 (Secretin Family Receptors) Pathway (106378); Developmental Biology Pathway (477129); Disease Pathway (530764); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Integrated Pancreatic Cancer Pathway (711360); Maturity Onset Diabetes Of The Young Pathway (83096)
ncbi summary :
This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]
uniprot summary :
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.