catalog number :
MBS856164
products full name :
SGK269 Antibody
products short name :
SGK269
products name syn :
Pseudopodium-enriched atypical kinase 1; Sugen kinase 269; Tyrosine-protein kinase SgK269; PEAK1; KIAA2002
other names :
pseudopodium-enriched atypical kinase 1; Pseudopodium-enriched atypical kinase 1; pseudopodium-enriched atypical kinase 1; sugen kinase 269; NKF3 kinase family member; tyrosine-protein kinase SgK269; pseudopodium-enriched atypical kinase 1; Sugen kinase 269; Tyrosine-protein kinase SgK269
products gene name :
SGK269
other gene names :
PEAK1; PEAK1; SGK269; KIAA2002
uniprot entry name :
PEAK1_HUMAN
specificity :
SGK269 antibody detects endogenous levels of total SGK269 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500~1:1000, ELISA: 1:5000
other info1 :
Reactivity Note: Human (Identities = 100%, Positives = 100%)
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human SGK269. Pathway: Phosphatases/Kinases
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Zody M.C., Nature 440:671-675(2006). Jikuya H., Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. Ohara O., DNA Res. 9:47-57(2002). -----------------------------------------------------------------------------------------------------------
ncbi acc num :
NP_079052.2
ncbi gb acc num :
NM_024776.3
ncbi mol weight :
193,106 Da
ncbi summary :
This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
uniprot summary :
PEAK1: Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN. Belongs to the protein kinase superfamily. Protein type: Kinase, protein; Protein kinase, Other; EC 2.7.10.2; Protein kinase, Ser/Thr (non-receptor); Other group; NKF3 family. Chromosomal Location of Human Ortholog: 15q24.3. Cellular Component: nucleoplasm; focal adhesion; cytoplasm; plasma membrane; actin cytoskeleton. Molecular Function: protein binding; non-membrane spanning protein tyrosine kinase activity; ATP binding. Biological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation