AGTR2 Antibody | MyBioSource MBS856162 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

AGTR2 Antibody

catalog :

MBS856162

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS856162

products type :

Antibody

products full name :

AGTR2 Antibody

products short name :

AGTR2

other names :

AGTR2, partial; Type-2 angiotensin II receptor; type-2 angiotensin II receptor; angiotensin II type-2 receptor; angiotensin II receptor, type 2; Angiotensin II type-2 receptor; AT2

products gene name :

AGTR2

other gene names :

AGTR2; AGTR2; AT2; ATGR2; MRX88; AT2

uniprot entry name :

AGTR2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

363

form :

Lyophilized anti-AGTR2 antibody purified by peptide affinity column containing 1% BSA and 0.02% NaN3

concentration :

100ug/200ul

storage stability :

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.

tested application :

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

app notes :

Peptide ELISA titer: 1:10,000-1:40,000. Western blot analysis: 1:1,000-1:2,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.

other info1 :

Source Note: Rabbit polyclonal AGTR2 (1) antibody was raised against a peptide from C terminal residues of human AGTR2 protein. Reactivity Note: Not yet tested in other species.

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

ncbi gi num :

49456893

ncbi acc num :

CAG46767.1

uniprot acc num :

P50052

ncbi mol weight :

41,184 Da

ncbi pathways :

ACE Inhibitor Pathway (198763); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)

ncbi summary :

The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010]

uniprot summary :

AT2: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Defects in AGTR2 are the cause of mental retardation X- linked type 88 (MRX88). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: Xq22-q23. Cellular Component: integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; extracellular region. Molecular Function: receptor antagonist activity; protein binding; angiotensin type II receptor activity; peptide hormone binding; transcription factor binding. Biological Process: positive regulation of phosphoprotein phosphatase activity; regulation of transcription factor import into nucleus; negative regulation of icosanoid secretion; positive regulation of nitric oxide biosynthetic process; negative regulation of heart rate; negative regulation of nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; renin-angiotensin regulation of aldosterone production; dopamine biosynthetic process; positive regulation of vasodilation; angiotensin mediated vasodilation involved in regulation of systemic arterial blood pressure; cerebellar cortex development; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; cell surface receptor linked signal transduction; regulation of blood pressure; positive regulation of cell proliferation; inflammatory response; cellular sodium ion homeostasis; positive regulation of nitric-oxide synthase activity; response to organic nitrogen; negative regulation of blood vessel endothelial cell migration; brain renin-angiotensin system; G-protein coupled receptor protein signaling pathway; negative regulation of fibroblast proliferation; G-protein signaling, coupled to cGMP nucleotide second messenger; blood vessel remodeling; brain development; negative regulation of cell growth; nitric oxide mediated signal transduction; positive regulation of cytokine secretion

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage