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Connexin 43 Antibody

MBS856051

0.1 mg

280 USD

Antibody

Connexin 43 Antibody

[Connexin 43]

[CXA1; CXN-43; GJA1; Gap junction 43 kDa heart protein; Gap junction alpha-1 protein]

[gap junction alpha-1 protein; Gap junction alpha-1 protein; gap junction alpha-1 protein; gap junction protein alpha 1; Connexin-43; Cx43; Gap junction 43 kDa heart protein]

[CX43]

[GJA1; GJA1; HSS; CMDR; CX43; EKVP; GJAL; ODDD; AVSD3; EKVP3; HLHS1; PPKCA; GJAL; Cx43]

Human, Mouse, Rat

382

Connexin 43 antibody detects endogenous levels of total Connexin 43 protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at -20°C for 1 year

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

WB: 1:500~1:1000. IHC: 1:50~1:100. IF: 1:100~1:500. ELISA: 1:10000

Immunohistochemistry (IHC)

Western Blot (WB)

Immunofluorescence (IF)

Immunogen: The antiserum was produced against synthesized peptide derived from human Connexin 43.

Toshihiko Toyofuku, J. Biol. Chem., May 1998; 273: 12725. Toshihiko Toyofuku, J. Biol. Chem., Jan 1998; 273: 1519. Masayuki Shimada, Biol Reprod, Apr 2001; 64: 1255. Merry L. Lindsey, Circulation, Jun 2006; 113: 2919-2928.

4504001

NP_000156.1

NM_000165.4

P17302

Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Calcium Regulation In The Cardiac Cell Pathway (198906); EGFR1 Signaling Pathway (198782); Formation Of Annular Gap Junctions Pathway (105934); Gap Junction Pathway (83072); Gap Junction Pathway (483); Gap Junction Assembly Pathway (105928); Gap Junction Degradation Pathway (105933)

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles ().

0.1 mg

280 USD