UBF (Phospho-Ser484) Antibody | MyBioSource MBS855937 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

UBF (Phospho-Ser484) Antibody

catalog :

MBS855937

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS855937

products type :

Antibody

products full name :

UBF (Phospho-Ser484) Antibody

products short name :

UBF

products name syn :

Autoantigen NOR-90; Nucleolar transcription factor 1; TCFUBF; UBF-1; UBF1; UBTF; Upstream binding factor 1

other names :

nucleolar transcription factor 1 isoform b; Nucleolar transcription factor 1; nucleolar transcription factor 1; autoantigen NOR-90; 90-kDa nucleolus organizer region autoantigen; upstream binding transcription factor, RNA polymerase I; Autoantigen NOR-90; Upstream-binding factor 1; UBF-1

products gene name :

UBF

other gene names :

UBTF; UBTF; UBF; UBF1; UBF2; UBF-1; NOR-90; UBF; UBF1; UBF-1

uniprot entry name :

UBF1_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

727

specificity :

UBF (Phospho-Ser484) antibody detects endogenous levels of UBF only when phosphorylated at serine 484.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:1000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human UBF around the phosphorylation site of serine 484 (P-E-SP-P-K). All Sites: Human: Ser484; Mouse: Ser484; Rat: Ser484. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Jantzen H.M., Nature 344:830-836(1990). Chan E.K.L., J. Exp. Med. 174:1239-1244(1991). The MGC Project Team; Genome Res. 14:2121-2127(2004).

ncbi gi num :

115529451

ncbi acc num :

NP_001070151.1

ncbi gb acc num :

NM_001076683.1

uniprot acc num :

P17480

ncbi mol weight :

84,937 Da

ncbi pathways :

Epigenetic Regulation Of Gene Expression Pathway (980449); Gene Expression Pathway (105937); Negative Epigenetic Regulation Of RRNA Expression Pathway (980452); NoRC Negatively Regulates RRNA Expression Pathway (980454); RNA Polymerase I Chain Elongation Pathway (106555); RNA Polymerase I Promoter Clearance Pathway (106551); RNA Polymerase I Promoter Escape Pathway (106554); RNA Polymerase I Promoter Opening Pathway (106552); RNA Polymerase I Transcription Pathway (106550); RNA Polymerase I Transcription Initiation Pathway (106553)

ncbi summary :

This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

uniprot summary :

UBF: a transcription factor that recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. Activate RNA polymerase II-regulated, beta-catenin-responsive promoters. Interacts with TAF1, a factor involved in the transcription of cell cycle and growth regulatory genes. It binds specifically to the upstream control element. Two splice variant isoforms have been described. Protein type: Nucleolus; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 17q21.31. Cellular Component: nucleoplasm; nucleolus. Molecular Function: protein binding; DNA binding; chromatin binding. Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase I promoter; regulation of transcription, DNA-dependent; negative regulation of gene expression, epigenetic; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; gene expression; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; regulation of gene expression, epigenetic; positive regulation of transcription from RNA polymerase I promoter

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage