other

TRIM24 Antibody

MBS855796

0.1 mg

280 USD

Antibody

TRIM24 Antibody

[TRIM24]

[TIF1; TIF1A; TRIM24; Transcription intermediary factor 1-alpha; Tripartite motif protein 24; kinase TIF1-alpha]

[transcription intermediary factor 1-alpha isoform b; Transcription intermediary factor 1-alpha; transcription intermediary factor 1-alpha; tripartite motif containing 24; E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alphaCurated; Tripartite motif-containing protein 24]

[TRIM24]

[TRIM24; TRIM24; PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA; RNF82; TIF1; TIF1A; TIF1-alpha]

Human, Mouse

1016

TRIM24 antibody detects endogenous levels of total TRIM24 protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1mg/ml

Store at-20 degree C for 1 year.

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB: 1:500~1:1000. IHC: 1:50~1:100. ELISA: 1:20000

Testing Data

Immunohistochemistry (IHC)

Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human TRIM24.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Thenot S., J. Biol. Chem. 272:12062-12068(1997). Venturini L., Oncogene 18:1209-1217(1999). Hellal-Levy C., Mol. Endocrinol. 14:1210-1221(2000).

47419909

NP_003843.3

NM_003852.3

O15164

Disease Pathway (530764); Regulation Of Androgen Receptor Activity Pathway (138027); Signaling By FGFR In Disease Pathway (645274); Signaling By FGFR Mutants Pathway (645275); Signaling By FGFR1 Fusion Mutants Pathway (645278); Signaling By FGFR1 Mutants Pathway (645276)

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes ().

0.1 mg

280 USD