antibody

NPSR1 Antibody

MBS855786

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

Antibody

NPSR1 Antibody

NPSR1

neuropeptide S receptor isoform B; Neuropeptide S receptor; neuropeptide S receptor; G-protein coupled receptor 154; G-protein coupled receptor PGR14; vasopressin receptor-related receptor 1; G-protein coupled receptor for asthma susceptibility; neuropeptide S receptor 1; G-protein coupled receptor 154; G-protein coupled receptor PGR14; G-protein coupled receptor for asthma susceptibility

NPSR1

NPSR1; NPSR1; GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154; GPR154; GPRA; PGR14

NPSR1_HUMAN

Polyclonal

Rabbit

Human

377

Lyophilized anti-NPSR1 antibody purified by protein A column containing 0.02% NaN3

100ug/200ul

Western Blot (WB)

Peptide ELISA titer: 1:40,000-1:80,000. Western blot analysis: 1:200-1,000. Optimal dilutions/concentrations should be determined by the end user.

Source Note: Rabbit polyclonal NPSR1 (1) antibody was raised against a 15 amino acid peptide corresponding to the C terminus residues of human NPSR1 protein. Reactivity Note: Not yet tested in other species.

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

(1) D'Amato,M., Zucchelli,M., Seddighzadeh, M., et al. Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis. PLoS ONE 5 (2), E9315 (2010)

46391085

NP_997056

NM_207173.1

10,612 Da

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Peptide Ligand-binding Receptors Pathway (106358); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

NPSR1: May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases. Defects in NPSR1 are a cause of asthma-related traits type 2 (ASRT2). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 9 isoforms of the human protein are produced by alternative splicing. Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 7p14.3. Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane. Molecular Function: neuropeptide receptor activity; vasopressin receptor activity. Biological Process: neuropeptide signaling pathway; positive regulation of release of sequestered calcium ion into cytosol. Disease: Asthma-related Traits, Susceptibility To, 2

0.1 mg

290 USD