product summary
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company name :
MyBioSource
product type :
antibody
product name :
ACER1
catalog :
MBS855774
quantity :
0.1 mg
price :
320 USD
clonality :
polyclonal
host :
unidentified
conjugate :
nonconjugated
reactivity :
human
more info or order :
image
image 1 :
image 2 :
product information
catalog number :
MBS855774
products type :
Antibody
products full name :
ACER1
products short name :
[ACER1]
other names :
[alkaline ceramidase 1; Alkaline ceramidase 1; alkaline ceramidase 1; alkaline ceramidase 1; Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3]
products gene name :
[ACER1]
other gene names :
[ACER1; ACER1; ASAH3; ALKCDase1; ASAH3; AlkCDase 1; Alkaline CDase 1]
clonality :
Polyclonal
host :
unknown
reactivity :
Human. Not yet tested in other species.
sequence length :
264
form :
Lyophilized anti -ACER1antibody purified by peptide affinity column containing 0.5% BSA and 0.02% NaN 3 .
storage stability :
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20°C after reconstitution. Avoid repeated freeze/defrost cycles.
tested application :
Peptide ELISA titer: 1:5,000-1:10,000 . Western blot analysis: 1:500-1:1,000. Immunohistochemistry: 1:100-500 . Optimal dilutions/concentrations should be determined by the end user.
app notes :
Peptide ELISA: 1:5,000-1:10,000. WB: 1:500-1:1,000. IHC: 1:100-500
image1 heading :
Testing Data
image2 heading :
Testing Data
other info1 :
Host Note: Rabbit polyclonal ACER1 (1) antibody was raised against a peptide from C terminal residues of human ACER1 protein.
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products description :
Rabbit polyclonal ACER1 (1) antibody was raised against a peptide from C terminal residues of human ACER1 protein.
products references :
(1) Sun, W., Xu, R., Hu, W., et al. Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. J. Invest. Dermatol. 128 (2), 389-397 (2008).
ncbi gi num :
19424128
ncbi acc num :
NP_597999.1
ncbi gb acc num :
NM_133492.2
uniprot acc num :
Q8TDN7
ncbi pathways :
Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Sphingolipid De Novo Biosynthesis Pathway (530750); Sphingolipid Metabolism Pathway (82994); Sphingolipid Metabolism Pathway (119543); Sphingolipid Metabolism Pathway (369); Sphingolipid Signaling Pathway (1144995); Sphingolipid Signaling Pathway (1158200); Sphingosine Biosynthesis Pathway (524497)
ncbi summary :
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]
uniprot summary :
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids ().
size1 :
0.1 mg
price1 :
320 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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