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BATF Antibody

MBS855740

0.1 mg

280 USD

Antibody

BATF Antibody

[BATF]

[B-ATF; SF-HT-activated gene 2 protein; SFA-2]

[basic leucine zipper transcriptional factor ATF-like; Basic leucine zipper transcriptional factor ATF-like; basic leucine zipper transcriptional factor ATF-like; basic leucine zipper ATF-like transcription factor; B-cell-activating transcription factor; B-ATF; SF-HT-activated gene 2 protein; SFA-2]

[BATF]

[BATF; BATF; SFA2; B-ATF; BATF1; SFA-2; B-ATF; SFA-2]

Human, Mouse

125

BATF antibody detects endogenous levels of total BATF protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Immunohistochemistry (IHC), ELISA (EIA)

IHC: 1:50-1:100. ELISA: 1:1000

Immunohistochemistry (IHC)

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human BATF.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Dorsey M.J., Oncogene 11:2255-2265(1995). Hasegawa H., Biochem. Biophys. Res. Commun. 222:164-170(1996). Meyer N.P., Mamm. Genome 9:849-852(1998).

5453563

NP_006390.1

NM_006399.3

Q16520

14,120 Da

The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8+ dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8+ dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8+ T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs ().

0.1 mg

280 USD