PSMD12 Antibody | MyBioSource MBS855714 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PSMD12 Antibody

catalog :

MBS855714

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS855714

products type :

Antibody

products full name :

PSMD12 Antibody

products short name :

PSMD12

products name syn :

26S proteasome non-ATPase regulatory 12; 26S proteasome regulatory p55; proteasome (prosome; macropain) 26S; non-ATPase; 12; proteasome 26S non-ATPase 12; proteasome 26S non-ATPase 12 isoform 1 variant; PSD12

other names :

26S proteasome non-ATPase regulatory subunit 12 isoform 1; 26S proteasome non-ATPase regulatory subunit 12; 26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; 26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55

products gene name :

PSMD12

other gene names :

PSMD12; PSMD12; p55; Rpn5

uniprot entry name :

PSD12_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

456

specificity :

PSMD12 antibody detects endogenous levels of total PSMD12 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:40000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%) Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human PSMD12. Pathway: Translation

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Saito A., Gene 203:241-250(1997). Suzuki Y., Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. Gevaert K., Nat. Biotechnol. 21:566-569(2003). ---------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

4506221

ncbi acc num :

NP_002807.1

ncbi gb acc num :

NM_002816.3

uniprot acc num :

O00232

ncbi mol weight :

50,579 Da

ncbi pathways :

AMER1 Mutants Destabilize The Destruction Complex Pathway (1016198); APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway (1016193); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1016194); APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (105825); APC/C:Cdc20 Mediated Degradation Of Securin Pathway (105833); APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (105831); APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway (105835); AUF1 (hnRNP D0) Destabilizes MRNA Pathway (187212); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1016197); AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway (1016195)

ncbi summary :

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. [provided by RefSeq, Jul 2008]

uniprot summary :

PSMD12: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the proteasome subunit p55 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Proteasome complex; Protease. Chromosomal Location of Human Ortholog: 17q24.2. Cellular Component: nucleoplasm; proteasome complex; membrane; proteasome regulatory particle; cytosol. Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage