LAMA4 Antibody | MyBioSource MBS855508 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LAMA4 Antibody

catalog :

MBS855508

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS855508

products type :

Antibody

products full name :

LAMA4 Antibody

products short name :

LAMA4

products name syn :

Laminin subunit alpha-4 [Precursor]; LAMA4

other names :

laminin subunit alpha-4 isoform 1; Laminin subunit alpha-4; laminin subunit alpha-4; laminin alpha 4 chain; laminin, alpha 4; Laminin-14 subunit alpha; Laminin-8 subunit alpha; Laminin-9 subunit alpha

products gene name :

LAMA4

other gene names :

LAMA4; LAMA4; LAMA3; CMD1JJ; LAMA4*-1

uniprot entry name :

LAMA4_HUMAN

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

1823

specificity :

LAMA4 antibody detects endogenous levels of total LAMA4 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:40000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human LAMA4. Pathway: Adhesion

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Iivanainen A., FEBS Lett. 365:183-188(1995). Richards A.J., Eur. J. Biochem. 238:813-821(1996). Mungall A.J., Nature 425:805-811(2003). ------------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

380503843

ncbi acc num :

NP_001098676.2

ncbi gb acc num :

NM_001105206.2

uniprot acc num :

Q16363

ncbi mol weight :

12,819 Da

ncbi pathways :

African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); ECM Proteoglycans Pathway (833812); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262); FOXM1 Transcription Factor Network Pathway (137935); Focal Adhesion Pathway (198795)

ncbi summary :

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

uniprot summary :

LAMA4: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide; Extracellular matrix; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 6q21. Cellular Component: extracellular matrix; laminin-1 complex; extracellular region; basement membrane; basal lamina. Molecular Function: protein binding; extracellular matrix structural constituent; receptor binding. Biological Process: regulation of cell adhesion; extracellular matrix organization and biogenesis; regulation of embryonic development; cell adhesion; regulation of cell migration. Disease: Cardiomyopathy, Dilated, 1jj

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage