catalog number :
MBS855406
products full name :
CIB2 Antibody
products short name :
CIB2
products name syn :
Calcium and integrin-binding family member 2; Kinase-interacting protein 2; KIP 2; CIB2; KIP2
other names :
calcium and integrin-binding family member 2 isoform 2; Calcium and integrin-binding family member 2; calcium and integrin-binding family member 2; DNA-dependent protein kinase catalytic subunit-interacting protein 2; calcium and integrin binding family member 2; Kinase-interacting protein 2; KIP 2
products gene name :
CIB2
other gene names :
CIB2; CIB2; KIP2; USH1J; DFNB48; KIP2; KIP 2
uniprot entry name :
CIB2_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
CIB2 antibody detects endogenous levels of total CIB2 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Immunohistochemistry (IHC), ELISA (EIA)
app notes :
IHC: 1:50~1:100, ELISA: 1:5000
other info1 :
Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human CIB2. Pathway: Cytoskeletal
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Seki N., Biochim. Biophys. Acta 1444:143-147(1999). The MGC Project Team, Genome Res. 14:2121-2127(2004). ------------------------------------------------------------------------------------------------------------------------------------------
ncbi acc num :
NP_001258817.1
ncbi gb acc num :
NM_001271888.1
ncbi mol weight :
15,816 Da
ncbi summary :
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
uniprot summary :
CIB2: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process. Protein type: Calcium-binding. Chromosomal Location of Human Ortholog: 15q24. Cellular Component: muscle tendon junction; photoreceptor inner segment; neuromuscular junction; sarcolemma. Molecular Function: integrin binding; protein binding; calcium ion binding. Biological Process: calcium ion homeostasis; photoreceptor cell maintenance. Disease: Deafness, Autosomal Recessive 48; Usher Syndrome, Type Ij