catalog number :
MBS855385
products full name :
PPP2R3C Antibody
products short name :
[PPP2R3C]
products name syn :
[Protein phosphatase subunit G5PR; Rhabdomyosarcoma antigen MU-RMS-40.6A; Rhabdomyosarcoma antigen Mu-RMS-40.6C]
other names :
[serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; protein phosphatase 2 regulatory subunit B''gamma; Protein phosphatase subunit G5PR; Rhabdomyosarcoma antigen MU-RMS-40.6A/6C]
products gene name :
[PPP2R3C]
other gene names :
[PPP2R3C; PPP2R3C; G4-1; G5pr; C14orf10; C14orf10; G5PR]
reactivity :
Human ( Identities=100% , Positives = 100) . Mouse ( Identities=100% , Positives = 100). Rat ( Identities=100% , Positives = 100).
specificity :
PPP2R3C antibody detects endogenous levels of total PPP2R3C protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20°C for 1 year.
tested application :
Western Blot (WB), ELISA (EIA)
image1 heading :
Testing Data #2
other info1 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human PPP2R3C.
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products references :
Kamnasaran D., Genomics 85:608-621(2005). Ota T., Nat. Genet. 36:40-45(2004). Mural R.J., Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
ncbi acc num :
NP_001292084.1
ncbi gb acc num :
NM_001305155.1
ncbi pathways :
AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Dopaminergic Synapse Pathway (469199); Dopaminergic Synapse Pathway (469185); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979); Sphingolipid Signaling Pathway (1144995); Sphingolipid Signaling Pathway (1158200)
ncbi summary :
This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
uniprot summary :
May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.