catalog number :
MBS855285
products full name :
CNKR1 Antibody
products short name :
[CNKR1]
products name syn :
[Connector enhancer of KSR1; hCNK1; Connector enhancer of KSR-like; CNK homolog protein 1]
other names :
[connector enhancer of kinase suppressor of ras 1 isoform 2; Connector enhancer of kinase suppressor of ras 1; connector enhancer of kinase suppressor of ras 1; connector enhancer of kinase suppressor of Ras 1; CNK homolog protein 1; CNK1; hCNK1; Connector enhancer of KSR-like]
products gene name :
[CNKR1]
other gene names :
[CNKSR1; CNKSR1; CNK; CNK1; CNK1; Connector enhancer of KSR 1; CNK1; hCNK1]
reactivity :
Human, Mouse, Rat
specificity :
CNKR1 antibody detects endogenous levels of total CNKR1 protein.
purity :
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year.
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500-1:1000. ELISA: 1:10000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human CNKR1.
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products references :
Therrien M., Cell 95:343-353(1998). The MGC Project Team, Genome Res. 14:2121-2127(2004). Jaffe A.B., Mol. Cell. Biol. 24:1736-1746(2004).
ncbi acc num :
NP_001284576.1
ncbi gb acc num :
NM_001297647.1
ncbi mol weight :
78,790 Da
ncbi pathways :
ARMS-mediated Activation Pathway (1269471); Axon Guidance Pathway (1270303); Cytokine Signaling In Immune System Pathway (1269310); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Developmental Biology Pathway (1270302); Downstream Signal Transduction Pathway (1269479); Downstream Signaling Of Activated FGFR1 Pathway (1269392); Downstream Signaling Of Activated FGFR2 Pathway (1269403); Downstream Signaling Of Activated FGFR3 Pathway (1269413)
ncbi summary :
This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
uniprot summary :
May function as an adapter protein or regulator of Ras signaling pathways.