ALK (Phospho-Tyr1604) Antibody | MyBioSource MBS855239 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ALK (Phospho-Tyr1604) Antibody

catalog :

MBS855239

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS855239

products type :

Antibody

products full name :

ALK (Phospho-Tyr1604) Antibody

products short name :

ALK

products name syn :

ALK tyrosine kinase receptor precursor; Anaplastic lymphoma kinase; CD246; EC 2.7.10.1; kinase ALK

other names :

ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; CD246 antigen; mutant anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; Anaplastic lymphoma kinase; CD_antigen: CD246

products gene name :

ALK

other gene names :

ALK; ALK; CD246; NBLST3

uniprot entry name :

ALK_HUMAN

host :

Rabbit

reactivity :

Human

sequence length :

1620

specificity :

ALK (Phospho-Tyr1604) antibody detects endogenous levels of ALK only when phosphorylated at tyrosine 1604.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1mg/ml

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:20000

other info1 :

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human ALK around the phosphorylation site of tyrosine 1604 (G-H-YP-E-D). All Sites: Human: Tyr1604. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Morris S.W., Oncogene 14:2175-2188(1997). Hillier L.W., Nature 434:724-731(2005). Simonitsch I., FASEB J. 15:1416-1418(2001).

ncbi gi num :

29029632

ncbi acc num :

NP_004295.2

ncbi gb acc num :

NM_004304.4

uniprot acc num :

Q9UM73

ncbi mol weight :

176,442 Da

ncbi pathways :

Non-small Cell Lung Cancer Pathway (83119); Non-small Cell Lung Cancer Pathway (531)

ncbi summary :

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

uniprot summary :

ALK: a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors. Protein type: Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; Oncoprotein; EC 2.7.10.1; TK group; Alk family. Chromosomal Location of Human Ortholog: 2p23. Cellular Component: protein complex; integral to plasma membrane. Molecular Function: NF-kappaB-inducing kinase activity; protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding. Biological Process: regulation of apoptosis; cell proliferation; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; neuron development; signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; activation of NF-kappaB transcription factor. Disease: Neuroblastoma, Susceptibility To, 3

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage