catalog number :
MBS855216
products full name :
k-ras Antibody
products short name :
k-ras
other names :
Homo sapiens Kirsten rat sarcoma viral oncogene homolog (KRAS), transcript variant a, mRNA; GTPase KRas; GTPase KRas; K-Ras 2; c-Ki-ras; oncogene KRAS2; K-ras p21 protein; c-Kirsten-ras protein; PR310 c-K-ras oncogene; transforming protein p21; cellular c-Ki-ras2 proto-oncogene; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; Kirsten rat sarcoma viral oncogene homolog; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-rasCleaved into the following chain:GTPase KRas, N-terminally processed
products gene name :
k-ras
other gene names :
KRAS; KRAS; NS; NS3; CFC2; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS2; RASK2
uniprot entry name :
RASK_HUMAN
form :
Lyophilized anti-k-ras antibody purified by peptide affinity column containing 2% BSA and 0.02% NaN3
concentration :
100ug/200ul
tested application :
Western Blot (WB)
app notes :
Peptide ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:200-1,000. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal k-ras (1) antibody was raised against a peptide near intermediate residues of human k-ras protein. Reactivity Note: Not yet tested in other species.
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
(1) Estrada,P., Rojas-Atencio,A., Zabala,W., et al. Frequency and clinicopathological associations of K-ras mutations in Venezuelan patients with colo-rectal cancer. Invest Clin 50 (1), 55-63 (2009)
ncbi acc num :
NP_203524.1
ncbi gb acc num :
NM_033360
ncbi mol weight :
21,425 Da
ncbi pathways :
ARMS-mediated Activation Pathway 106466!!Activation Of RAS In B Cells Pathway 576252!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adaptive Immune System Pathway 366160!!Alcoholism Pathway 585563!!Alcoholism Pathway 587116!!Aldosterone-regulated Sodium Reabsorption Pathway 130626!!Aldosterone-regulated Sodium Reabsorption Pathway 130590!!Axon Guidance Pathway 83065
ncbi summary :
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]