GAD1 Antibody | MyBioSource MBS855195 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GAD1 Antibody

catalog :

MBS855195

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS855195

products type :

Antibody

products full name :

GAD1 Antibody

products short name :

GAD1

products name syn :

4.1.1.15; GLUTAMATE DECARBOXYLASE; BRAIN; 67-KD; glutamate decarboxylase 1 (brain; 67kD); lutamate decarboxylase 1 (brain; 67kDa); glutamate decarboxylase 1 isoform GAD25; glutamate decarboxylase 1 isoform GAD67

other names :

glutamate decarboxylase 1 isoform GAD67; Glutamate decarboxylase 1; glutamate decarboxylase 1; GAD-67; 67 kDa glutamic acid decarboxylase; glutamate decarboxylase 67 kDa isoform; glutamate decarboxylase 1 (brain, 67kDa); 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform

products gene name :

GAD1

other gene names :

GAD1; GAD1; GAD; SCP; CPSQ1; GAD; GAD67; GAD-67

uniprot entry name :

DCE1_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

594

specificity :

GAD67 antibody detects endogenous levels of total GAD67 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

100ug/100ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:10000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from human GAD67. Pathway: Neuroscience

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Jamil Kanaani, J. Biol. Chem., Dec 1999; 274: 37200. Susan M. Murphy, J. Histochem. Cytochem., Nov 1998; 46: 1261. M. Gierdalski, Cereb Cortex, Sep 2001; 11: 806 - 815. Kyung Soo Kim, Diabetes, Sep 2002; 51: 2764.

ncbi gi num :

58331246

ncbi acc num :

NP_000808.2

ncbi gb acc num :

NM_000817.2

uniprot acc num :

Q99259

ncbi mol weight :

47,440 Da

ncbi pathways :

Alanine And Aspartate Metabolism Pathway (198783); Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Biogenic Amine Synthesis Pathway (198793); Butanoate Metabolism Pathway (83007); Butanoate Metabolism Pathway (391); GABA (gamma-Aminobutyrate) Shunt Pathway (413433); GABA (gamma-Aminobutyrate) Shunt Pathway (468220); GABA Synthesis Pathway (187175); GABA Synthesis, Release, Reuptake And Degradation Pathway (187174)

ncbi summary :

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]

uniprot summary :

GAD67: Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Other Amino Acids Metabolism - taurine and hypotaurine; EC 4.1.1.15; Lyase; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - butanoate; Mitochondrial. Chromosomal Location of Human Ortholog: 2q31. Cellular Component: plasma membrane; vesicle membrane; intracellular. Molecular Function: protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; protein N-terminus binding; pyridoxal phosphate binding. Biological Process: response to drug; glutamate catabolic process; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; gamma-aminobutyric acid biosynthetic process; protein-pyridoxal-5-phosphate linkage; neurotransmitter biosynthetic process. Disease: Cerebral Palsy, Spastic Quadriplegic, 1

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage