antibody

BMPR1A Antibody

MBS855162

0.1 mg

320 USD

polyclonal

domestic rabbit

nonconjugated

human, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

BMPR1A Antibody

[BMPR1A]

[bone morphogenetic protein receptor type-1A; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor type 1A; Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD_antigen: CD292]

[BMPR1A]

[BMPR1A; BMPR1A; ALK3; SKR5; CD292; ACVRLK3; 10q23del; ACVRLK3; ALK3; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5]

Polyclonal

Rabbit

Human. Predicted: Mouse, Rat

532

Purified by protein affinity column containing 0.02% NaN3

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

ELISA: 1:20,000-1:80,000. WB: 1:1,000-1:2,000. IHC: 1:100-1:500

Testing Data

Testing Data

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Rabbit polyclonal BMPR1A (1) antibody was raised against a recombinate human BMPR1A protein 219-453aa (BC028383).

(1) Giambra, V., Cianci, R., Lolli, S., et al. Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration. J. Immunol. 183 (12), 8280-8285 (2009).

41349437

NP_004320.2

NM_004329.2

P36894

60,198 Da

BMP Signalling And Regulation Pathway (198910); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Endochondral Ossification Pathway (198812); Heart Development Pathway (198802); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Integrated Breast Cancer Pathway (219801); Signal Transduction Pathway (477114); Signaling By BMP Pathway (106336)

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.

0.1 mg

320 USD