NRF1 Antibody | MyBioSource MBS855113 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

NRF1 Antibody

catalog :

MBS855113

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS855113

products type :

Antibody

products full name :

NRF1 Antibody

products short name :

NRF1

products name syn :

Nuclear respiratory factor 1; NRF-1; Alpha palindromic-binding protein; Alpha-pal; NRF1

other names :

nuclear respiratory factor 1 isoform 1; Nuclear respiratory factor 1; nuclear respiratory factor 1; alpha palindromic-binding protein; nuclear respiratory factor 1; Alpha palindromic-binding protein; Alpha-pal

products gene name :

NRF1

other gene names :

NRF1; NRF1; ALPHA-PAL; NRF-1; Alpha-pal

uniprot entry name :

NRF1_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

503

specificity :

NRF1 antibody detects endogenous levels of total NRF1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:1000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human NRF1. Pathway: Growth Factors

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Virbasius C.A., Genes Dev. 7:2431-2445(1993). Efiok B.J.S., J. Biol. Chem. 269:18921-18930(1994). Gopalakrishnan L., J. Biol. Chem. 270:18019-18025(1995). ----------------------------------------------------------------------------------------------------------

ncbi gi num :

93141039

ncbi acc num :

NP_001035199.1

ncbi gb acc num :

NM_001040110.1

uniprot acc num :

Q16656

ncbi mol weight :

55,674 Da

ncbi pathways :

Energy Metabolism Pathway (198907); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Mitochondrial Gene Expression Pathway (198757); Mitochondrial Biogenesis Pathway (980486); Organelle Biogenesis And Maintenance Pathway (980485); PPARA Activates Gene Expression Pathway (530749)

ncbi summary :

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

uniprot summary :

NRF1: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 7q32. Cellular Component: nucleoplasm; cytoplasm. Biological Process: mitochondrion organization and biogenesis; generation of precursor metabolites and energy; organ regeneration; transcription, DNA-dependent; organelle organization and biogenesis; response to lipopolysaccharide; cellular lipid metabolic process; response to estradiol stimulus; regulation of transcription from RNA polymerase II promoter; response to folic acid; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage