GR (Phospho-Ser203) Antibody | MyBioSource MBS854915 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GR (Phospho-Ser203) Antibody

catalog :

MBS854915

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS854915

products type :

Antibody

products full name :

GR (Phospho-Ser203) Antibody

products short name :

products name syn :

GCR; glucocorticoid receptor; GRL; GRL1; NR3C1

other names :

glucocorticoid receptor isoform alpha; Glucocorticoid receptor; glucocorticoid receptor; glucocorticoid nuclear receptor variant 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); Nuclear receptor subfamily 3 group C member 1

products gene name :

other gene names :

NR3C1; NR3C1; GR; GCR; GRL; GCCR; GCRST; GRL; GR

uniprot entry name :

GCR_HUMAN

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

777

specificity :

GR (Phospho-Ser203) antibody detects endogenous levels of GR only when phosphorylated at serine 203.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:10000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 93%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human GR around the phosphorylation site of serine 203 (S-G-SP-P-G). All Sites: Human: Ser203; Mouse: Ser202. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Hollenberg S.M., Nature 318:635-641(1985). Encio I.J., J. Biol. Chem. 266:7182-7188(1991). Munroe D.G., Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases. ----------------------------------------------------------------------------

ncbi gi num :

4504133

ncbi acc num :

NP_000167.1

ncbi gb acc num :

NM_000176.2

uniprot acc num :

P04150

ncbi mol weight :

82,904 Da

ncbi pathways :

Adipogenesis Pathway (198832); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); Circadian Clock Pathway (187173); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Glucocorticoid Receptor Regulatory Network Pathway (138014); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Nuclear Receptor Transcription Pathway (105979)

ncbi summary :

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

uniprot summary :

GR: transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described. Protein type: DNA-binding; Nuclear receptor; Transcription factor; Mitochondrial. Chromosomal Location of Human Ortholog: 5q31.3. Cellular Component: nucleoplasm; membrane; mitochondrial matrix; cytoplasm; cytosol; nucleus. Molecular Function: protein dimerization activity; protein binding; glucocorticoid receptor activity; zinc ion binding; transcription factor activity; steroid binding. Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; adrenal gland development; maternal behavior; regulation of glucocorticoid biosynthetic process; chromatin modification; signal transduction; glucocorticoid mediated signaling; glucocorticoid metabolic process; regulation of transcription, DNA-dependent; glucocorticoid receptor signaling pathway; positive regulation of neuron apoptosis; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of gluconeogenesis. Disease: Glucocorticoid Resistance, Generalized

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage