Prostate-specific Antigen Antibody | MyBioSource MBS854901 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Prostate-specific Antigen Antibody

catalog :

MBS854901

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS854901

products type :

Antibody

products full name :

Prostate-specific Antigen Antibody

products short name :

Prostate-specific Antigen

products name syn :

3.4.21.77; APS; KLK2A1; PSA; gamma-seminoprotein; hK3; semenogelase; seminin; ANTIGEN; PROSTATE-SPECIFIC; P-30 antigen; PROSTATE-SPECIFIC ANTIGEN; kallikrein 3; (prostate specific antigen); prostate specific antigen isoform 1 preproprotein; prostate specific antigen isoform 2

other names :

prostate-specific antigen isoform 3 preproprotein; Prostate-specific antigen; prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen; kallikrein-related peptidase 3; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase

other gene names :

KLK3; KLK3; APS; PSA; hK3; KLK2A1; APS; PSA; Seminin

uniprot entry name :

KLK3_HUMAN

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

238

specificity :

Prostate-specific Antigen antibody detects endogenous levels of total prostate-specific Antigen protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

100ug/100ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from human prostate-specific Antigen. Pathway: Intermediates

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Carsten Stephan, Cancer Epidemiol. Biomarkers Prev., Nov 2000; 9: 1133. Steven P. Balk, J. Clin. Oncol., Jan 2003; 21: 383 - 391. Deuk Jae Sung, J. Ultrasound Med., May 2004; 23: 615 - 622. Kinnari Patel, Clin. Cancer Res., Nov 2004; 10: 7511 - 7519.

ncbi gi num :

71834853

ncbi acc num :

NP_001025218.1

ncbi gb acc num :

NM_001030047.1

uniprot acc num :

P07288

ncbi mol weight :

25,116 Da

ncbi pathways :

Androgen Receptor Signaling Pathway (198806); Coregulation Of Androgen Receptor Activity Pathway (138085); FOXA1 Transcription Factor Network Pathway (137979); Metabolism Of Proteins Pathway (106230); Pathways In Cancer (83105); Prostate Cancer Pathway (755440); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Regulation Of Androgen Receptor Activity Pathway (138027); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)

ncbi summary :

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

PSA: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily. Protein type: Secreted; Secreted, signal peptide; EC 3.4.21.77; Protease. Chromosomal Location of Human Ortholog: 19q13.41. Cellular Component: extracellular region; nucleus. Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity. Biological Process: negative regulation of angiogenesis; cellular protein metabolic process; proteolysis

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage