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CNOT7 Antibody

MBS854889

0.1 mg

280 USD

Antibody

CNOT7 Antibody

[CNOT7]

[BTG1 binding factor 1; BTG1-binding factor 1; CCR4-NOT transcription complex; 7; CCR4-associated factor 1; carbon catabolite repressor protein (CCR4)-associative factor 1]

[CCR4-NOT transcription complex subunit 7 isoform 2; CCR4-NOT transcription complex subunit 7; CCR4-NOT transcription complex subunit 7; CCR4-NOT transcription complex subunit 7; BTG1-binding factor 1; CCR4-associated factor 1; CAF-1; Caf1a]

[CNOT7]

[CNOT7; CNOT7; CAF1; CAF-1; Caf1a; hCAF-1; CAF1; CAF-1]

Human, Mouse

244

CNOT7 antibody detects endogenous levels of total CNOT7 protein.

The antibody was affinity purified from rabbit antisesum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline(without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/mL

Store at-20°C for 1 year.

Western Blot (WB), ELISA (EIA)

WB: 1:500~1:1000. ELISA: 1:20000

Western Blot (WB)

Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human CNOT7.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Bogdan J.A., Biochem. J. 336:471-481(1998). The MGC Project Team; Genome Res. 14:2121-2127(2004).

1015576845

NP_001309016.1

NM_001322087.1

Q9UIV1

Deadenylation Of MRNA Pathway (1269713); Deadenylation-dependent MRNA Decay Pathway (1269712); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); RNA Degradation Pathway (117291); RNA Degradation Pathway (116127); TP53 Regulates Transcription Of Cell Cycle Genes Pathway (1383071); TP53 Regulates Transcription Of Additional Cell Cycle Genes Whose Exact Role In The P53 Pathway Remain Uncertain (1383074); Transcriptional Regulation By TP53 Pathway (1269654)

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

0.1 mg

280 USD