catalog number :
MBS854788
products full name :
TAGAP Antibody
products short name :
TAGAP
products name syn :
T-cell activation Rho GTPase-activating protein; T-cell activation GTPase-activating protein; TAGAP; TAGAP1; FKSG15
other names :
T-cell activation Rho GTPase-activating protein isoform d; T-cell activation Rho GTPase-activating protein; T-cell activation Rho GTPase-activating protein; T-cell activation RhoGTPase activating protein; T-cell activation GTPase-activating protein
products gene name :
TAGAP
other gene names :
TAGAP; TAGAP; FKSG15; IDDM21; TAGAP1; ARHGAP47; TAGAP1
uniprot entry name :
TAGAP_HUMAN
specificity :
TAGAP antibody detects endogenous levels of total TAGAP protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Immunohistochemistry (IHC), ELISA (EIA)
app notes :
IHC: 1:50~1:100, ELISA: 1:1000
other info1 :
Reactivity Note: Human (Identities = 100%, Positives = 100%)
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human TAGAP. Pathway: GTP-binding
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Mao M., Genomics 83:989-999(2004). Wang Y.-G., Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases. Ota T.,Nat. Genet. 36:40-45(2004). -----------------------------------------------------------------------------------------------------------
ncbi acc num :
NP_001265662.1
ncbi gb acc num :
NM_001278733.1
ncbi mol weight :
29,977 Da
ncbi pathways :
Rho GTPase Cycle Pathway (106503); Signal Transduction Pathway (477114); Signaling By Rho GTPases Pathway (106502)
ncbi summary :
This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
uniprot summary :
TAGAP: an apparent GTPase-activating protein (GAP) for Rho monomeric G proteins. May play important roles during T-cell activation. Mutations have been associated with various autoimmune conditions including rheumatoid arthritis, Crohn¿s disease, and celiac disease. Four isoforms of the human protein are produced by alternative splicing. Protein type: GAPs; GAPs, Rac/Rho. Chromosomal Location of Human Ortholog: 6q25.3. Cellular Component: cytosol. Molecular Function: guanyl-nucleotide exchange factor activity. Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity