hnRNP A2/B1 Antibody | MyBioSource MBS854787 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

hnRNP A2/B1 Antibody

catalog :

MBS854787

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS854787

products type :

Antibody

products full name :

hnRNP A2/B1 Antibody

products short name :

hnRNP A2/B1

products name syn :

HNRPA2B1; Heterogeneous nuclear ribonucleoproteins A2/B1; ROA2; hnRNP A2 / hnRNP B1

other names :

heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2; Heterogeneous nuclear ribonucleoproteins A2/B1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; nuclear ribonucleoprotein particle A2 protein; heterogeneous nuclear ribonucleoprotein A2/B1

products gene name :

hnRNP A2/B1

other gene names :

HNRNPA2B1; HNRNPA2B1; RNPA2; HNRPA2; HNRPB1; SNRPB1; HNRNPA2; HNRNPB1; IBMPFD2; HNRPA2B1; HNRPA2B1; hnRNP A2/B1

uniprot entry name :

ROA2_HUMAN

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

341

specificity :

hnRNP A2/B1 antibody detects endogenous levels of total hnRNP A2/B1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IF: 1:100~1:500, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human hnRNP A2/B1. Pathway: Transcription

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Burd C.G., Proc. Natl. Acad. Sci. U.S.A. 86:9788-9792(1989). Kozu T., Genomics 25:365-371(1995). Biamonti G., Nucleic Acids Res. 22:1996-2002(1994). ------------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

4504447

ncbi acc num :

NP_002128.1

ncbi gb acc num :

NM_002137.3

uniprot acc num :

P22626

ncbi mol weight :

36,006 Da

ncbi pathways :

Gene Expression Pathway (105937); Processing Of Capped Intron-Containing Pre-mRNA Pathway (160950); MRNA Splicing Pathway (105951); MRNA Splicing - Major Pathway (105952); MRNA Processing Pathway (198843)

ncbi summary :

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

hnRNP A2/B1: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Spliceosome; RNA-binding; RNA splicing. Chromosomal Location of Human Ortholog: 7p15. Cellular Component: nucleoplasm; spliceosome; membrane; cytoplasm; ribonucleoprotein complex; nucleus. Molecular Function: protein binding; single-stranded telomeric DNA binding; RNA binding; nucleotide binding. Biological Process: nuclear mRNA splicing, via spliceosome; negative regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; negative regulation of transcription from RNA polymerase II promoter; mRNA processing; RNA transport. Disease: Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 2

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage