catalog number :
MBS854723
products full name :
MGST1 Antibody
products short name :
[MGST1]
products name syn :
[EC 2.5.1.18; Microsomal glutathione S-transferase 1; Microsomal GST-1; Microsomal GST-I]
other names :
[microsomal glutathione S-transferase 1 isoform a; Microsomal glutathione S-transferase 1; microsomal glutathione S-transferase 1; microsomal glutathione S-transferase 1; Microsomal GST-I]
products gene name :
[MGST1]
other gene names :
[MGST1; MGST1; MGST; GST12; MGST-I; GST12; MGST; Microsomal GST-1]
reactivity :
Human (Identities = 100%, Positives = 100%)
specificity :
MGST1 antibody detects endogenous levels of total MGST1 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
In phosphate buffered saline (without Mg 2+ and Ca 2+ ), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year.
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500~1:1000, ELISA: 1:10000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human MGST1.
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products references :
Dejong J.L., J. Biol. Chem. 263:8430-8436(1988). Kelner M.J., Genomics 36:100-103(1996). Lee S.H., Biochim. Biophys. Acta 1446:389-396(1999).
ncbi acc num :
NP_001247440.1
ncbi gb acc num :
NM_001260511.1
ncbi pathways :
Biological Oxidations Pathway (105698); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Drug Metabolism - Cytochrome P450 Pathway (83032); Drug Metabolism - Cytochrome P450 Pathway (427); Glutathione Conjugation Pathway (105727); Glutathione Metabolism Pathway (82973); Glutathione Metabolism Pathway (343); Metabolism Pathway (477135); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (83031)
ncbi summary :
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
uniprot summary :
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.