CRMP-2 (Phospho-Thr509) Antibody | MyBioSource MBS854616 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CRMP-2 (Phospho-Thr509) Antibody

catalog :

MBS854616

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS854616

products type :

Antibody

products full name :

CRMP-2 (Phospho-Thr509) Antibody

products short name :

CRMP-2

products name syn :

Collapsin response mediator protein 2; CRMP2; Dihydropyrimidinase related protein-2; DPYL2; DPYSL2; DRP-2; N2A3; TOAD-64; Turned on after division; 64 kDa protein; ULIP 2 protein; ULIP2

other names :

dihydropyrimidinase-related protein 2 isoform 1; Dihydropyrimidinase-related protein 2; dihydropyrimidinase-related protein 2; unc-33-like phosphoprotein 2; collapsin response mediator protein hCRMP-2; dihydropyrimidinase-like 2; Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2

products gene name :

CRMP-2

other gene names :

DPYSL2; DPYSL2; DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2; CRMP2; ULIP2; DRP-2; CRMP-2; ULIP-2

uniprot entry name :

DPYL2_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

677

specificity :

CRMP-2 (Phospho-Thr509) antibody detects endogenous levels of CRMP-2 only when phosphorylated at threonine 509.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:1000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human CRMP-2 around the phosphorylation site of threonine 509 (S-V-TP-PK). All Sites: Human: Thr509; Mouse: Thr509; Rat: Thr509. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Miki Y., Science 266:66-71(1994). Smith T.M., Genome Res. 6:1029-1049(1996). Wilson C.A., Oncogene 14:1-16(1997).

ncbi gi num :

308818195

ncbi acc num :

NP_001184222.1

ncbi gb acc num :

NM_001197293.2

uniprot acc num :

Q16555

ncbi mol weight :

58,163 Da

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); BDNF Signaling Pathway (712093); CRMPs In Sema3A Signaling Pathway (119525); Developmental Biology Pathway (477129); L1CAM Interactions Pathway (161003); Recycling Pathway Of L1 (161004); Regulation Of Microtubule Cytoskeleton Pathway (755439); Semaphorin Interactions Pathway (119519)

ncbi summary :

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

uniprot summary :

CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)). Protein type: Motility/polarity/chemotaxis; Microtubule-binding. Chromosomal Location of Human Ortholog: 8p22-p21. Cellular Component: microtubule; growth cone; cell soma; membrane; mitochondrion; dendrite; terminal button; cytosol. Molecular Function: dihydropyrimidinase activity; protein binding; protein kinase binding. Biological Process: response to drug; nervous system development; axon guidance; olfactory bulb development; response to amphetamine; positive regulation of glutamate secretion; synaptic vesicle transport; cytoskeleton organization and biogenesis; endocytosis; response to cocaine; signal transduction; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage