PDGFR alpha Antibody | MyBioSource MBS854527 product information

product summary

company name :

MyBioSource

product type :

other

product name :

PDGFR alpha Antibody

catalog :

MBS854527

quantity :

0.1 mg

price :

280 USD

more info or order :

MyBioSource product webpage

image

image 1 :

Peptide-+

image 2 :

Immunohistochemical analysis of paraffin-embedded human brain tissue using PDGFR alpha antibody. Western blot analysis of extracts from HepG2 cells, using PDGFR alpha antibody.

image 3 :

Peptide-+ Immunofluorescence analysis of HeLa cells, using PDGFR alpha antibody.

product information

catalog number :

MBS854527

products type :

Antibody

products full name :

PDGFR alpha Antibody

products short name :

[PDGFR alpha]

products name syn :

[Alpha platelet-derived growth factor receptor precursor; CD140a; PDGF-R-alpha; PDGFR-alpha; PGFRA; kinase PDGFR-alpha]

other names :

[platelet-derived growth factor receptor alpha isoform 1; Platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor alpha; platelet derived growth factor receptor alpha; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; PDGFR-2; CD_antigen: CD140a]

products gene name :

[PDGFR alpha]

other gene names :

[PDGFRA; PDGFRA; CD140A; PDGFR2; PDGFR-2; PDGFR2; RHEPDGFRA; PDGF-R-alpha; PDGFR-alpha; PDGFR-2]

reactivity :

Human, Mouse, Rat

sequence length :

1089

specificity :

PDGFR alpha antibody detects endogenous levels of total PDGFR alpha protein.

purity :

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at-20 degree C for 1 year.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1:500~1:1000. IHC: 1:50~1:100. IF: 1:100~1:500. ELISA: 1:20000

image1 heading :

Testing Data

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunofluorescence (IF)

other info1 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human PDGFR alpha.

products references :

Jennifer Brennan, Genes & Dev., Mar 2003; 17: 800. JC Yu, J. Biol. Chem., Apr 1994; 269: 10668-10674. Nobuyuki Takakura, J. Histochem. Cytochem., Jun 1997; 45: 883.

ncbi gi num :

1115538446

ncbi acc num :

NP_001334758.1

ncbi gb acc num :

NM_001347829.1

uniprot acc num :

P16234

ncbi mol weight :

82,809 Da

ncbi pathways :

ARMS-mediated Activation Pathway (1269471); ATF-2 Transcription Factor Network Pathway (138006); Adaptive Immune System Pathway (1269171); Allograft Rejection Pathway (920963); Angiogenesis Pathway (198772); Axon Guidance Pathway (1270303); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cardiac Progenitor Differentiation Pathway (712094); Central Carbon Metabolism In Cancer Pathway (1059538)

ncbi summary :

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]

uniprot summary :

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

size1 :

0.1 mg

price1 :

280 USD

more info or order :

MyBioSource product webpage