product summary
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company name :
MyBioSource
product type :
antibody
product name :
IL18RAP Antibody
catalog :
MBS854523
quantity :
0.1 mg
price :
290 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
product information
catalog number :
MBS854523
products type :
Antibody
products full name :
IL18RAP Antibody
products short name :
IL18RAP
other names :
interleukin-18 receptor accessory protein; Interleukin-18 receptor accessory protein; interleukin-18 receptor accessory protein; IL-18 receptor beta; interleukin-1 receptor 7; interleukin-18 receptor beta; IL-18 receptor accessory protein; cluster of differentiation w218b; CD218 antigen-like family member B; interleukin 18 receptor accessory protein; Accessory protein-like; AcPL; CD218 antigen-like family member B; CDw218b; IL-1R accessory protein-like; IL-1RAcPL; Interleukin-1 receptor 7; IL-1R-7; IL-1R7; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta; IL-18R-beta; IL-18Rbeta; CD_antigen: CD218b
other gene names :
IL18RAP; IL18RAP; ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta; IL1R7; IL-18 receptor accessory protein; IL-18RAcP; AcPL; IL-1RAcPL; IL-1R-7; IL-1R7; IL-18R-beta; IL-18Rbeta
uniprot entry name :
I18RA_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human
sequence length :
599
form :
Lyophilized IL18RAP antibody purified by protein affinity column containing 0.02% NaN3
concentration :
100ug/200ul
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:1,000-1:2,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal IL18RAP (1) antibody was raised against a recombinate human IL18RAP protein 380-599aa (BC106765). Reactivity Note: Predicted: Mouse, Rat; Not yet tested in other species.
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
(1) Franke,A., McGovern,D.P., Barrett,J.C., et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 42 (12), 1118-1125 (2010)
ncbi gi num :
4504657
ncbi acc num :
NP_003844.1
ncbi gb acc num :
NM_003853.3
ncbi mol weight :
51,945 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL12 Signaling Mediated By STAT4 Pathway (137936); IL12-mediated Signaling Events Pathway (137922); IL23-mediated Signaling Events Pathway (138000); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797)
ncbi summary :
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
uniprot summary :
IL18RAP: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Belongs to the interleukin-1 receptor family. Protein type: Membrane protein, integral; Cell surface. Chromosomal Location of Human Ortholog: 2q12. Cellular Component: integral to membrane. Molecular Function: receptor activity. Biological Process: cell surface receptor linked signal transduction; immune response; inflammatory response
size1 :
0.1 mg
price1 :
290 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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