GOT2 Antibody | MyBioSource MBS854446 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GOT2 Antibody

catalog :

MBS854446

quantity :

0.1 mg

price :

355 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS854446

products type :

Antibody

products full name :

GOT2 Antibody

products short name :

GOT2

other names :

aspartate aminotransferase, mitochondrial isoform 1; Aspartate aminotransferase, mitochondrial; aspartate aminotransferase, mitochondrial; FABP-1; FABPpm; mAspAT; transaminase A; aspartate transaminase 2; fatty acid-binding protein; aspartate aminotransferase 2; kynurenine aminotransferase 4; kynurenine aminotransferase IV; glutamate oxaloacetate transaminase 2; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; plasma membrane-associated fatty acid-binding protein; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); glutamic-oxaloacetic transaminase 2, mitochondrial; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A

products gene name :

GOT2

other gene names :

GOT2; GOT2; KAT4; KATIV; mitAAT; mAspAT; FABP-1; FABPpm

uniprot entry name :

AATM_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

host :

Mouse

sequence length :

430

specificity :

Anti-GOT2 recognizes GOT2 expression in HepG2 whole cell lysate.

form :

Each vial contains 100 ug IgG in 100 ul of citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.

storage stability :

The antibody may be stored at -20 degree C for one year in its original formulation. Additionally, antibody may be stored at 2 degree C to 8 degree C for up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody.

tested application :

ELISA (EIA), Western Blot (WB-Re), Western Blot (WB-Ce), Immunohistochemistry (IHC)

other info1 :

Source Note: Purified mouse monoclonal antibody generated using E Coli expressed recombinant protein GOT2 as immunogen.

other info2 :

Immunogen: Recombinant protein corresponding to fragment (aa/225-430) GOT2.

products categories :

Plant antibody

ncbi gi num :

73486658

ncbi acc num :

NP_002071.2

ncbi gb acc num :

NM_002080.2

ncbi mol weight :

43,030 Da

ncbi pathways :

2-Oxocarboxylic Acid Metabolism Pathway (714485); 2-Oxocarboxylic Acid Metabolism Pathway (717400); 4-hydroxyproline Degradation Pathway (139122); Alanine And Aspartate Metabolism Pathway (198783); Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Biosynthesis Of Amino Acids Pathway (790012)

ncbi summary :

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

uniprot summary :

GOT2: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Protein type: EC 2.6.1.7; Mitochondrial; Transferase; EC 2.6.1.1; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - alanine, aspartate and glutamate. Chromosomal Location of Human Ortholog: 16q21. Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane; plasma membrane. Molecular Function: kynurenine-oxoglutarate transaminase activity; aspartate transaminase activity; pyridoxal phosphate binding. Biological Process: glutamate metabolic process; oxaloacetate metabolic process; glutamate catabolic process to aspartate; glucose metabolic process; aspartate biosynthetic process; pathogenesis; gluconeogenesis; 2-oxoglutarate metabolic process; response to ethanol; 4-hydroxyproline catabolic process; carbohydrate metabolic process; aspartate catabolic process; aspartate metabolic process; glutamate catabolic process to 2-oxoglutarate; amino acid biosynthetic process; fatty acid transport

size1 :

0.1 mg

price1 :

355 USD

more info or order :

MyBioSource product webpage