catalog number :
MBS854391
products full name :
MtSSB Antibody
products short name :
MtSSB
products name syn :
Mt-SSB; MtSSB; PWP1-interacting protein 17; SSB; SSBP; single-stranded DNA-binding protein; mitochondrial
other names :
single-stranded DNA-binding protein, mitochondrial; Single-stranded DNA-binding protein, mitochondrial; single-stranded DNA-binding protein, mitochondrial; PWP1-interacting protein 17; single-stranded DNA binding protein 1, mitochondrial; PWP1-interacting protein 17
products gene name :
MtSSB
other gene names :
SSBP1; SSBP1; SSBP; mtSSB; Mt-SSB; SOSS-B1; SSBP; Mt-SSB; MtSSB
uniprot entry name :
SSBP_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
MtSSB antibody detects endogenous levels of total MtSSB protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
app notes :
WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:1000
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human MtSSB. Pathway: Transcription
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Tiranti V., Gene 126:219-225(1993). Matsuoka S., Science 316:1160-1166(2007). Yang C., Nat. Struct. Biol. 4:153-157(1997). ------------------------------------------------------------------------------------------------------------------------------------------
ncbi acc num :
NP_001243439.1
ncbi gb acc num :
NM_001256510.1
ncbi mol weight :
17,260 Da
ncbi pathways :
DNA Replication Pathway (83039); DNA Replication Pathway (444); Homologous Recombination Pathway (83046); Homologous Recombination Pathway (454); Mismatch Repair Pathway (83045); Mismatch Repair Pathway (453); Mitochondrial Biogenesis Pathway (980486); Organelle Biogenesis And Maintenance Pathway (980485); Transcriptional Activation Of Mitochondrial Biogenesis Pathway (980488)
ncbi summary :
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
uniprot summary :
SSBP1: This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA. Protein type: RNA-binding; Mitochondrial. Chromosomal Location of Human Ortholog: 7q34. Cellular Component: mitochondrion; mitochondrial matrix; nucleus. Molecular Function: protein binding; chromatin binding; single-stranded DNA binding. Biological Process: positive regulation of helicase activity; mitochondrion organization and biogenesis; organelle organization and biogenesis; DNA replication