catalog number :
MBS854377
products full name :
HYAL2/hyaluronoglucosaminidase 2 Antibody
products short name :
HYAL2/hyaluronoglucosaminidase 2
other names :
Homo sapiens hyaluronoglucosaminidase 2 (HYAL2), transcript variant 1, mRNA; Hyaluronidase-2; hyaluronidase-2; hyal-2; PH20 homolog; PH-20 homolog; hyaluronidase 2; lysosomal hyaluronidase; lung carcinoma protein 2; hyaluronoglucosaminidase-2; hyaluronoglucosaminidase 2; Hyaluronoglucosaminidase-2; Lung carcinoma protein 2; LuCa-2
other gene names :
HYAL2; HYAL2; LUCA2; LUCA2; Hyal-2; LuCa-2
uniprot entry name :
HYAL2_HUMAN
form :
Lyophilized anti-HYAL2 antibody purified by peptide affinity column containing 2% BSA and 0.02% NaN3
concentration :
100ug/200ul
tested application :
Immunohistochemistry (IHC)
app notes :
Peptide ELISA titer: 1:1,000-1:10,000. Immunohistochemistry: 1:50-200. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal HYAL2 (1) antibody was raised against a peptide near intermediate residues of human HYAL2 protein. Reactivity Note: Not yet tested in other species.
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
(1) Nykopp,T.K., Rilla,K., Sironen,R., et al. Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content. BMC Cancer 9, 143 (2009)
ncbi acc num :
NP_003764.3
ncbi gb acc num :
NM_003773
ncbi mol weight :
53,860 Da
ncbi pathways :
Chondroitin Sulfate Degradation Pathway 413376!!Chondroitin Sulfate Degradation Pathway 468247!!Dermatan Sulfate Degradation Pathway 413375!!Dermatan Sulfate Degradation Pathway 468240!!Disease Pathway 530764!!Glycogen Storage Diseases Pathway 980468!!Glycosaminoglycan Degradation Pathway 82981!!Glycosaminoglycan Degradation Pathway 355!!Glycosaminoglycan Metabolism Pathway 645297!!Hyaluronan Metabolism Pathway 645298
ncbi summary :
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]