catalog number :
MBS854362
products full name :
ABCC10 Antibody
products short name :
ABCC10
other names :
ABCC10 protein; Multidrug resistance-associated protein 7; multidrug resistance-associated protein 7; ATP-binding cassette sub-family C member 10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; ATP-binding cassette sub-family C member 10
products gene name :
ABCC10
other gene names :
ABCC10; ABCC10; MRP7; SIMRP7; EST182763; MRP7; SIMRP7
uniprot entry name :
MRP7_HUMAN
form :
Lyophilized anti-ABCC10 antibody purified by peptide affinity column containing 1% BSA and 0.02% NaN3
concentration :
100ug/200ul
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Peptide ELISA titer: 1:10,000-1:40,000. Western blot analysis: 1:500-1:1,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal ABCC10 (1) antibody was raised against a peptide from intermediate residues of human ABCC10 protein. Reactivity Note: Not yet tested in other species.
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
(1) Kuang,Y.H., Shen,T., Chen,X., et al. Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. Biochem. Pharmacol. 79 (2), 154-161 (2010)
ncbi acc num :
AAH24103.1
ncbi mol weight :
158,781 Da
ncbi pathways :
ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); Transmembrane Transport Of Small Molecules Pathway (106572)
ncbi summary :
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
uniprot summary :
ABCC10: ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: lysosomal membrane; integral to membrane; plasma membrane. Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATP binding. Biological Process: metabolic process; transmembrane transport