Trk C (Phospho-Tyr516) Antibody | MyBioSource MBS854301 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Trk C (Phospho-Tyr516) Antibody

catalog :

MBS854301

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS854301

products type :

Antibody

products full name :

Trk C (Phospho-Tyr516) Antibody

products short name :

Trk C

products name syn :

EC 2.7.10.1; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C

other names :

NT-3 growth factor receptor isoform a; NT-3 growth factor receptor; NT-3 growth factor receptor; GP145-TrkC; ETV6-NTRK3 fusion; tyrosine kinase receptor C; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; neurotrophic tyrosine kinase, receptor, type 3; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase

products gene name :

Trk C

other gene names :

NTRK3; NTRK3; TRKC; gp145(trkC); TRKC; Trk-C

uniprot entry name :

NTRK3_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

839

specificity :

Trk C (Phospho-Tyr516) antibody detects endogenous levels of Trk C only when phosphorylated at tyrosine 516.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:10000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Trk C around the phosphorylation site of tyrosine 516 (P-Q-YP-F-R). All Sites: Human: Tyr516; Mouse: Tyr516; Rat: Tyr516. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

McGregor L.M., Genomics 22:267-272(1994). Shelton D.L., J. Neurosci. 15:477-491(1995. Ichaso N., Oncogene 17:1871-1875(1998).

ncbi gi num :

59889562

ncbi acc num :

NP_001012338.1

ncbi gb acc num :

NM_001012338.2

uniprot acc num :

Q16288

ncbi mol weight :

91,833 Da

ncbi pathways :

BDNF Signaling Pathway (712093); Neurotrophic Factor-mediated Trk Receptor Signaling Pathway (137977); Neurotrophin Signaling Pathway (101143); Neurotrophin Signaling Pathway (100064)

ncbi summary :

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

uniprot summary :

TrkC: a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known. Protein type: Protein kinase, TK; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Trk family. Chromosomal Location of Human Ortholog: 15q25. Cellular Component: integral to plasma membrane; cytoplasm; receptor complex. Molecular Function: neurotrophin binding; protein binding; ephrin receptor binding; p53 binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding. Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; activation of MAPK activity; protein amino acid autophosphorylation; positive regulation of axon extension involved in regeneration; activation of protein kinase B; neuron migration; positive regulation of peptidyl-serine phosphorylation; response to ethanol; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; negative regulation of astrocyte differentiation; modification by virus of host cell transcription; neuron fate specification; response to axon injury; transmembrane receptor protein tyrosine kinase signaling pathway; response to corticosterone stimulus; positive regulation of cell migration

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage