product summary
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company name :
MyBioSource
product type :
antibody
product name :
CLK4 Antibody
catalog :
MBS854274
quantity :
0.1 mg
price :
215 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, enzyme immunoassay
more info or order :
product information
catalog number :
MBS854274
products type :
Antibody
products full name :
CLK4 Antibody
products short name :
CLK4
products name syn :
Dual specificity protein kinase CLK4; EC 2.7.12.1; CDC-like kinase 4; CLK4
other names :
dual specificity protein kinase CLK4; Dual specificity protein kinase CLK4; dual specificity protein kinase CLK4; protein serine threonine kinase Clk4; CDC-like kinase 4; CDC-like kinase 4
products gene name :
CLK4
other gene names :
CLK4; CLK4
uniprot entry name :
CLK4_HUMAN
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
481
specificity :
CLK4 antibody detects endogenous levels of total CLK4 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500~1:1000, ELISA: 1:1000
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human CLK4. Pathway: Phosphatases/Kinases
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Schultz J., Genomics 71:368-370(2001). McNally T., Protein Sci. 12:1562-1566(2003). Kantham L., Biochem. Biophys. Res. Commun. 304:125-129(2003). ------------------------------------------------------------------------------------------------------------------------------------------
ncbi gi num :
10190706
ncbi acc num :
NP_065717.1
ncbi gb acc num :
NM_020666.2
uniprot acc num :
Q9HAZ1
ncbi mol weight :
57,492 Da
ncbi pathways :
MRNA Processing Pathway (198843)
ncbi summary :
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
uniprot summary :
CLK4: a CMGC kinase of the CLK family. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. It has been reported to regulate splicing of genes such as Tau exon 10 in the mammalian nervous system. Expressed in liver, kidney, heart, muscle and brain. Clk4 mRNAs were expressed in the hippocampus, the cerebellum, and the olfactory bulb. Protein type: Protein kinase, dual-specificity (non-receptor); Kinase, protein; Protein kinase, CMGC; EC 2.7.12.1; CMGC group; CLK family. Chromosomal Location of Human Ortholog: 5q35. Cellular Component: nucleus. Molecular Function: protein serine/threonine kinase activity; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding. Biological Process: peptidyl-tyrosine phosphorylation; regulation of RNA splicing; protein amino acid autophosphorylation
size1 :
0.1 mg
price1 :
215 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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