ARHGEF11 Antibody | MyBioSource MBS854235 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ARHGEF11 Antibody

catalog :

MBS854235

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS854235

products type :

Antibody

products full name :

ARHGEF11 Antibody

products short name :

ARHGEF11

products name syn :

ARHGB; glutamate transporter EAAT4-associated protein 48; GTRAP48; PDZ-RhoGEF; rho guanine exchange factor (GEF) 11; rhoA-specific guanine nucleotide exchange factor; rhoGEF glutamate transport modulator

other names :

rho guanine nucleotide exchange factor 11 isoform 1; Rho guanine nucleotide exchange factor 11; rho guanine nucleotide exchange factor 11; Rho guanine exchange factor (GEF) 11; RhoGEF glutamate transport modulator; RhoA-specific guanine nucleotide exchange factor; glutamate transporter EAAT4-associated protein 48; Rho guanine nucleotide exchange factor (GEF) 11; PDZ-RhoGEF

products gene name :

ARHGEF11

other gene names :

ARHGEF11; ARHGEF11; GTRAP48; PDZ-RHOGEF; KIAA0380

uniprot entry name :

ARHGB_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1522

specificity :

ARHGEF11 antibody detects endogenous levels of total ARHGEF11 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1.0mg/ml, 100ug/100uL

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:5000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 93%, Positives = 93%); Rat (Identities = 93%, Positives = 93%);

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human ARHGEF11. Pathway: Intermediates

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Nagase T., DNA Res. 4:141-150(1997). Gregory S.G., Nature 441:315-321(2006). Ruemenapp U., FEBS Lett. 459:313-318(1999).

ncbi gi num :

7662086

ncbi acc num :

NP_055599.1

ncbi gb acc num :

NM_014784.3

uniprot acc num :

O15085

ncbi mol weight :

172,244 Da

ncbi pathways :

Axon Guidance Pathway (105688); Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (106443); Developmental Biology Pathway (477129); G Alpha (12/13) Signalling Events Pathway (106041); GPCR Downstream Signaling Pathway (119548); NRAGE Signals Death Through JNK Pathway (106444); Regulation Of RhoA Activity Pathway (138070); Rho GTPase Cycle Pathway (106503); Sema4D In Semaphorin Signaling Pathway (119520); Sema4D Induced Cell Migration And Growth-cone Collapse Pathway (119522)

ncbi summary :

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

ARHGEF11: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. 2 isoforms of the human protein are produced by alternative splicing. Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/Rho. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: membrane; cytoplasm; intracellular; cytosol. Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; G-protein-coupled receptor binding; GTPase activator activity. Biological Process: axon guidance; G-protein coupled receptor protein signaling pathway; regulation of small GTPase mediated signal transduction; striated muscle contraction; nerve growth factor receptor signaling pathway; establishment of cell polarity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; cytokinesis; regulation of cell growth; actin cytoskeleton organization and biogenesis; cell motility; Rho protein signal transduction

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage