product summary
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company name :
MyBioSource
product type :
antibody
product name :
NRL Antibody
catalog :
MBS854209
quantity :
0.1 mg
price :
215 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS854209
products type :
Antibody
products full name :
NRL Antibody
products short name :
NRL
products name syn :
Neural retina-specific leucine zipper protein; NRL; D14S46E
other names :
neural retina-specific leucine zipper protein; Neural retina-specific leucine zipper protein; neural retina-specific leucine zipper protein; neural retinal-specific leucine zipper; neural retina leucine zipper
products gene name :
NRL
other gene names :
NRL; NRL; RP27; D14S46E; NRL-MAF; D14S46E; NRL
uniprot entry name :
NRL_HUMAN
host :
Rabbit
reactivity :
Human
sequence length :
237
specificity :
NRL antibody detects endogenous levels of total NRL protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500~1:1000, ELISA: 1:10000
other info1 :
Reactivity Note: Human (Identities = 100%, Positives = 100%)
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human NRL. Pathway: Neuroscience
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Swaroop A., Proc. Natl. Acad. Sci. U.S.A. 89:266-270(1992). Farjo Q., Genomics 45:395-401(1997). Heilig R., Nature 421:601-607(2003).
ncbi gi num :
5453802
ncbi acc num :
NP_006168.1
ncbi gb acc num :
NM_006177.3
uniprot acc num :
P54845
ncbi mol weight :
11,276 Da
ncbi summary :
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]
uniprot summary :
NRL: Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B. Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant. Defects in NRL are a cause of retinal degeneration autosomal recessive clumped pigment type (RDCP). A retinopathy characterized by night blindness since early childhood, consistent with a severe reduction in rod function. Color vision is normal although there is a relatively enhanced function of short-wavelength-sensitive cones in the macula. Signs of retinal degeneration and clusters of clumped pigment deposits in the peripheral fundus at the level of the retinal pigment epithelium are present (clumped pigmentary retinal degeneration). Belongs to the bZIP family. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 14q11.1-q11.2. Cellular Component: nucleus. Molecular Function: protein binding; leucine zipper domain binding; DNA binding. Biological Process: transcription from RNA polymerase II promoter; retinal rod cell development; positive regulation of rhodopsin gene expression; visual perception; response to stimulus; positive regulation of transcription from RNA polymerase II promoter; regulation of rhodopsin gene expression. Disease: Retinitis Pigmentosa 27
size1 :
0.1 mg
price1 :
215 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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