ALOXE3 Antibody | MyBioSource MBS854027 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ALOXE3 Antibody

catalog :

MBS854027

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS854027

products type :

Antibody

products full name :

ALOXE3 Antibody

products short name :

ALOXE3

other names :

arachidonate lipoxygenase 3, isoform CRA_b; Hydroperoxide isomerase ALOXE3; hydroperoxide isomerase ALOXE3; e-LOX-3; epidermal LOX-3; epidermal lipoxygenase; epidermis-type lipoxygenase 3; hydroperoxy icosatetraenoate dehydratase; arachidonate lipoxygenase 3; Epidermis-type lipoxygenase 3; Epidermal LOX-3; e-LOX-3; eLOX-3; Hydroperoxy icosatetraenoate dehydratase (EC:4.2.1.152)

products gene name :

ALOXE3

other gene names :

ALOXE3; ALOXE3; ARCI3; E-LOX; eLOX3; eLOX-3; Epidermal LOX-3; e-LOX-3; eLOX-3

uniprot entry name :

LOXE3_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

843

form :

Lyophilized ALOXE3 antibody purified by protein affinity column containing 1% BSA and 0.02% NaN3

concentration :

100ug/200ul

storage stability :

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:500-1:1,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.

other info1 :

Source Note: Rabbit polyclonal ALOXE3 (1) antibody was raised against a recombinate human ALOXE3 protein 334-599aa (BC104724). Reactivity Note: Predicted: Mouse, Rat; Not yet tested in other species.

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

ncbi gi num :

119610500

ncbi acc num :

BC104724

ncbi mol weight :

95,186 Da

ncbi summary :

This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

uniprot summary :

ALOXE3: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known. Defects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non- bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Belongs to the lipoxygenase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; EC 5.4.4.7; EC 4.2.1.152. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: cytoplasm. Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding; hepoxilin A3 synthase activity; iron ion binding; lyase activity. Biological Process: fat cell differentiation; sphingolipid metabolic process; lipoxygenase pathway; linoleic acid metabolic process; arachidonic acid metabolic process; ceramide biosynthetic process; hepoxilin biosynthetic process; sensory perception of pain. Disease: Ichthyosis, Congenital, Autosomal Recessive 3; Ichthyosis, Congenital, Autosomal Recessive 2

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage