FSHR Antibody | MyBioSource MBS853987 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FSHR Antibody

catalog :

MBS853987

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853987

products type :

Antibody

products full name :

FSHR Antibody

products short name :

FSHR

products name syn :

Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor; FSHR; LGR1

other names :

follicle-stimulating hormone receptor isoform 1; Follicle-stimulating hormone receptor; follicle-stimulating hormone receptor; FSH receptor; follitropin receptor; follicle stimulating hormone receptor; Follitropin receptor

products gene name :

FSHR

other gene names :

FSHR; FSHR; LGR1; ODG1; FSHRO; LGR1; FSH-R

uniprot entry name :

FSHR_HUMAN

host :

Rabbit

reactivity :

Human

sequence length :

695

specificity :

FSHR antibody detects endogenous levels of total FSHR protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Immunofluorescence (IF), ELISA (EIA)

app notes :

IF: 1:100~1:500, ELISA: 1:1000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human FSHR. Pathway: GPCR

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Minegish T., Biochem. Biophys. Res. Commun. 175:1125-1130(1991). Tilly J.L., Endocrinology 131:799-806(1992). Kelton C.A., Mol. Cell. Endocrinol. 89:141-151(1992).

ncbi gi num :

31657138

ncbi acc num :

NP_000136.2

ncbi gb acc num :

NM_000145.3

uniprot acc num :

P23945

ncbi mol weight :

81,974 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); FSH Signaling Pathway (672455); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); GPCRs, Other Pathway (198765); Hormone Ligand-binding Receptors Pathway (106369); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)

ncbi summary :

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

uniprot summary :

FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1. Chromosomal Location of Human Ortholog: 2p21-p16. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding; follicle-stimulating hormone receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; gonad development; follicle-stimulating hormone signaling pathway; male gonad development; female gamete generation; spermatogenesis; female gonad development. Disease: Ovarian Hyperstimulation Syndrome; Twinning, Dizygotic; Ovarian Dysgenesis 1

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage